Highly water dispersible boron based compounds are innovative and advanced materials which can be used in Boron Neutron Capture Therapy for cancer treatment (BNCT). Present study deals with the synthesis of highly water dispersible nanostructured Boron Nitride (BN). Unique and relatively low temperature synthesis route is the soul of present study. The morphological examinations (Scanning/trans...

UNLABELLED L-p-Boronophenylalanine (BPA) has been applied as a potential boron carrier for the treatment of malignant glioma in clinical boron neutron capture therapy (BNCT) since 1994. To provide the pharmacokinetics of BPA for clinical use of BNCT in Taiwan, 4-borono-2-(18)F-fluoro-L-phenylalanine-fructose ((18)F-FBPA-Fr) was synthesized and the biologic characteristics of this radiotracer in...

BACKGROUND The boron concentration (BC) in the blood, rather than in normal tissue, is often used as the reference to calculate the BC in tumor for boron neutron capture therapy (BNCT). The aims of this study were to justify whether BC in the blood is equal to that of normal tissue, and to verify the macro- and microdistributions of boron in tumor. MATERIALS AND METHODS BALB/c nude mice beari...

Boron neutron capture therapy (BNCT) is based on a nuclear capture reaction that occurs when boron-10, a stable isotope, is irradiated with low energy neutrons to produce high-energy alpha particles and recoiling lithium-7 nuclei. The purpose of the present study was to determine what urinary metabolites, if any, could be detected in patients with brain tumors who were given sodium borocaptate ...

The values of the parameters used in boron neutron capture therapy (BNCT) to calculate a given dose to human tissue vary with patients due to different physical, biological and/or medical circumstances. Parameters include the tissue dimensions, the 10B concentration and the relative biological effectiveness (RBE) factors for the different dose components associated with BNCT. Because there is s...

Boron neutron capture therapy (BNCT), a binary treatment modality that can potentially irradiate tumor tissue within cellular dimensions, is critically dependent on the preferential delivery of '"IS to individual neoplastic cells. In this study, ion microscopy was used to quantitatively evaluate the selectivity of p-boronophenylalanine-fructose (BPA-F) in the rat 9L gliosarcoma brain tumor mode...

A lithium fluoride (LiF)-silicon (Si)-based neutron detector was developed for real-time measurement of beams boron capture therapy (BNCT). Detection efficiencies thermal neutrons were measured at the national standard field in Japan and simulated using a Monte Carlo simulation code to evaluate absolute BNCT fluence rates. The detection agreed excellently with experimental results, within an er...

Advances in neutron-based radiation therapies such as Boron Neutron Capture Therapy (BNCT) pushes towards the development of new neutron spectrometers, whose key features are to be their practicability, reliability, energy resolution and detection range. The ACSpect is a novel spectrometer based on two-stages monolithic silicon telescope detector coupled an organic scintillator working active c...

Based on pharmacokinetic findings of fluorine-18labeled L-fluoroboronophenylalanine by positron emission tomography (PET), methods for estimating tumor iOB concentration were devised. In clinical practice of boron neutron capture therapy (BNCT) for high-grade gliomas, a large amount of L-boronophenylalanine (L iOB BPA)-fructose solution is used. Under these conditions, a slow i.v. infusion of L...