Introduction Frequently in joint replacement surgery, antibiotics are combined with acrylic cement to provide high local drug concentrations for prevention and treatment of infection. In 2003, the FDA approved the sale of single-antibiotic cement for use in septic arthroplasty cases. Such cements can now be purchased from various manufacturers. A major disadvantage of adding antibiotics to bone...

Calcium phosphates (CaPs) are the most widely used bone substitutes in bone tissue engineering due to their compositional similarities to bone mineral and excellent biocompatibility. In recent years, CaPs, especially hydroxyapatite and tricalcium phosphate, have attracted significant interest in simultaneous use as bone substitute and drug delivery vehicle, adding a new dimension to their appli...

Polymethylmethacrylate (PMMA) bone cement is a popular bone void filler for vertebroplasty. However, the use of PMMA has some drawbacks, including the material's excessive stiffness, exothermic polymerization, and short handling time. This study aimed to create an ideal modified bone cement to solve the above-mentioned problems. Modified bone cements were prepared by combining PMMA with three d...

Calcium phosphate cements (CPCs) with their biocompatibility, osteoconductivity and injectability plays an important role in bone defects treatment. Dual-setting cement is a promising approach to improve the physicochemical biological properties of CPCs which liquid phase contains dissolved monomers that polymerized during hardening process. In this study, series dual-setting were prepared by m...

The application of bone substitutes and cements has a long standing history in augmenting fractures as a complement to routine fracture fixation techniques. Nevertheless, such use is almost always in conjunction with definite means of fracture fixation such as intramedullary pins or bone plates. The idea of using biomaterials as the primary fixation bears the possibility of simultaneous fixatio...