Objective(s): Autologous bone transplantation known as the “gold standard” to reconstruction of osseous defects has known disadvantages. This study was designed to explore the effects of hydroxy-apatite/tricalcium-phosphate (HA/TCP) and platelet-rich plasma (PRP) on the osteogenesis ability of human adipose-derived mesenchymal stem cells (hAdMSCs) in vitro and in vivo. Materials and Methods: hA...

Abstract Engineering scaffolds to augment the repair of hard-to-soft multitissue musculoskeletal tissue units, such as bone-tendon, simultaneously support healing and functional movement has had limited success. Overcoming this challenge will require not only precise spatial control bone- tendon-like biomechanical properties, but also consideration resultant cues, well embedded biochemical cues...

BACKGROUND Excessive bone resorption by osteoclasts causes pathological bone destruction, seen in various bone diseases. There is accumulating evidence that certain herbal extracts have beneficial effects on bone metabolism. The fruits of Alpinia oxyphylla has been traditionally used for the treatment of diarrhea and enuresis. In this study, we investigated the effects of water extract of the f...

Chronic periodontitis, a common oral disease, usually results in irreversible bone resorption. Bone regeneration is a complex process between bone‑forming activity of osteoblasts and bone‑resorbing activity of osteoclasts, and still remains a challenge for physicians clinically. A previous study demonstrated that the mechanistic target of rapamycin signaling pathway is involved in osteogenic di...

Myocyte enhancement factor 2C (MEF2C) is a transcription studied in the development of skeletal and smooth muscles. Bone resorption studies have exhibited that reduced expression MEF2C contributes to osteopetrosis dysregulation pathological bone remodeling. Our current study aims determine how osteoclast differentiation analyze phenotype Mef2c-cKO mice (Cfms-cre; Mef2cfl/fl). qRT-PCR Western bl...

Background: Hair follicle stem cells (HFSCs) located in the bulge area has shown to be highly proliferative and could differentiate into neurons, glia, smooth muscle cell, and melanocytes in vitro. Simvastatin is an HMG-CoA reductase inhibitor that exerts pleiotropic effects beyond simple low-density lipoprotein lowering and has a similar impact on the differentiation of bone marrow stromal cel...

Bone is a dynamic organ that, once formed, undergoes constant remodeling process that includes bone resorption and synthesis. Osteoclasts osteoblasts are primarily responsible for controlling this process. X-box binding protein 1 (XBP1), transcription factor, affects the metabolism of bones in various ways. In recent years, numerous studies have revealed XBP1 plays vital role metabolism, includ...

Objective(s): Design and construction of biocompatible and biodegradable scaffolds are among the main goals of tissue engineering. Recently, use of nano-hydroxyapatite as a bioactive bioceramic agent with high similarity to the mineral phase of the human bone tissue, in combination with biodegradable polymers and implant coatings has attracted the attention of researchers in the field of biomat...

During development, growth factors and hormones cooperate to establish the unique sizes, shapes and material properties of individual bones. Among these, TGF-beta has been shown to developmentally regulate bone mass and bone matrix properties. However, the mechanisms that control postnatal skeletal integrity in a dynamic biological and mechanical environment are distinct from those that regulat...