مریم مقدم متین
دانشیار گروه زیست شناسی، گروه تحقیقاتی سلول‌های بنیادی، پژوهشکده فناوری زیستی، دانشکده علوم، دانشگاه فردوسی مشهد
[ 1 ] - بررسی هیستولوژیکی برهم‌کنش میان سلول‌های بنیادی مزانشیمی رت ویستار با ماتریکس لثه انسان در شرایط آزمایشگاهی
مقدمه: ماتریکس خارج سلولی بافت‌های طبیعی را می‌توان برداشت و به عنوان داربست زیستی برای بازسازی بافت‌ها و اندام‌ها بکار برد. در این مطالعه از ماتریکس سلول‌زدایی شده بافت لثه انسان، به عنوان داربستی جهت بررسی برهم‍کنش‍‌های هیستولوژیک میان سلول‌های بنیادی مزانشیمی گرفته شده از مغز استخوان رت ویستارو ماتریکس خارج سلولی بافت لثه انسان، استفاده گردید. مواد و روش‌ها: برای وصول به این هدف، ابتدا با...
[ 2 ] - Antioxidant, cytotoxic and DNA protective properties of Achillea eriophora DC. and Achillea biebersteinii Afan. extracts: A comparative study
Objective: Achillea is a traditional medicinal herb which contains different phenol and flavonoid compounds that are responsible for Achillea pharmacological effects. We aimed to determine phenol and flavonoid contents, besides antioxidant activities of different extracts from Achillea eriophoraa (A. eriophora) DC. and Achillea biebersteinii (A. biebersteinii) Afan. (endemic species in Iran) an...
[ 3 ] - The effect of platelet-rich plasma on human mesenchymal stem cell-induced bone regeneration of canine alveolar defects with calcium phosphate-based scaffolds
Objective(s): Autologous bone transplantation known as the “gold standard” to reconstruction of osseous defects has known disadvantages. This study was designed to explore the effects of hydroxy-apatite/tricalcium-phosphate (HA/TCP) and platelet-rich plasma (PRP) on the osteogenesis ability of human adipose-derived mesenchymal stem cells (hAdMSCs) in vitro and in vivo. Materials and Methods: hA...
[ 4 ] - Chemically primed bone-marrow derived mesenchymal stem cells show enhanced expression of chemokine receptors contributed to their migration capability
Objective(s):The limited homing potential of bone-marrow-derived mesenchymal stem cells (BM-MSC) is the key obstacle in MSC-based therapy. It is believed that chemokines and chemokine receptor interactions play key roles in cellular processes associated with migration. Meanwhile, MSCs express a low level of distinct chemokine receptors and they even lose these receptors on their surface after a...
[ 5 ] - Mesenchymal stem cells can survive on the extracellular matrix-derived decellularized bovine articular cartilage scaffold
Objective (s): The scarcity of articular cartilage defect to repair due to absence of blood vessels and tissue engineering is one of the promising approaches for cartilage regeneration. The objective of this study was to prepare an extracellular matrix derived decellularized bovine articular cartilage scaffold and investigate its interactions with seeded rat bone marrow mesenchymal stem cells (...
[ 6 ] - Effects of Human Adipose-derived Stem Cells and Platelet-rich Plasma on Healing Response of Canine Alveolar Surgical Bone Defects
Background: Due to the known disadvantages of autologous bone grafting, tissue engineering approaches have become an attractive method for ridge augmentation in dentistry. To the best of our knowledge, this is the first study conducted to evaluate the potential therapeutic capacity of PRP-assisted hADSCs seeded on HA/TCP granules on regenerative healing response of canine alveolar surgical bone...
[ 7 ] - Investigating Cellulase Producing Potential of Two Iranian Thermoascus aurantiacus Isolates in Submerged Fermentation
Cellulose is the most plentiful renewable biopolymer in nature which could be utilized by cellulolytic enzymes. Cellulases are among the most important groups of industrial enzymes which are widely consumed in biofuel production, pulp and paper, textile, and detergent industries. These enzymes can support a cleaner environment through reducing chemical processes in mentioned industries and agro...
[ 8 ] - بررسی اثر هورمون هیدروکورتیزون بر آسیبهای کلاستوژنیک کروموزومی القایی در رده سلولی L929 با استفاده از آزمون میکرونوکلئوس در سلول‌های دو هسته ای
هدف: در این مطالعه، تاثیر استرس بر القای آسیبهای ساختاری کروموزومی در شرایط in vitro در رده سلولی L929 با استفاده از آزمون میکرونوکلئوس در سلول‌های دو هستهای مورد بررسی قرار گرفت. مواد و روش‌ها: رده سلولی L929در محیط DMEM، حاوی 10 درصد FBS کشت داده شد. سلولها به چهار گروه آزمایشی شامل کنترل، گروه تیمار با Gy2 اشعه گاما، گروه تیمار با غلظتهای 25...
[ 9 ] - Mesenchymal Stem Cells: Interactions with Immune Cells and Immunosuppressive-Immunomodulatory Properties
Abstract Background and Objectives Recently, mesenchymal stem cells have attracted much attention in regenerative medicine and cell-based therapies. Mesenchymal stem cells are used in regenerative medicine mainly based on their capacity to differentiate into several cell lineages, low immunogenicity, and in particular their anti-inflammatory and immunosuppressive-immunomodulatory properties. ...
[ 10 ] - Human Amniotic Fluid Stem Cells: General Characteristics and Potential Therapeutic Applications
Introduction: Amniotic fluid contains a mixture of different cell types sloughed from the fetal skin, respiratory, alimentary and urogenital tracts, as well as the amnion membrane. As amniotic fluid develops prior to the process of gastrulation, many cells found in its heterogeneous population do not undergo lineage specialization. Therefore, amniotic fluid-derived mesenchymal stem cells (AF-MS...
[ 11 ] - Inhibition of esophageal cancer cell line (KYSE-30) proliferation using secondary metabolites of Ephedra endophyte bacteria
Regarding the rising rate of esophageal cancer in some parts of Asia, including northern and northeastern regions of Iran, the identification of new anti-cancer compounds is essential to combat the disease. The relation between some plants metabolites and these endophytic microorganisms are well characterized. In the current study, the potentials of Ephedra endophyte bacteria for the inhibition...
[ 12 ] - Major Epigenetic Changes in Polycystic Ovary Syndrome
Introduction: Polycystic Ovary Syndrome (PCOS) is one of the most common causes of female infertility. The etiology of this condition is complex. Various genetic and environmental factors have been identified in the pathogenesis of PCOS. The prevalence of this syndrome among Iranian females has been reported between 7.1% to 14.6%. Common symptoms include irregular menstruation, infertility, ova...
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