Osteoarthritis and lesions to cartilage tissue are diseases that frequently result in impaired joint function and patient disability. The treatment of osteoarthritis, along with local bone defects and systemic skeletal diseases, remains a significant clinical challenge for orthopaedic surgeons. Several bone morphogenetic proteins (BMPs) are known to have osteoinductive effects, whereof BMP-2 an...

BACKGROUND AND PURPOSE Bone morphogenetic proteins and their receptors are expressed in adult brains, and their expression levels increase after cerebral ischemia. The brain also expresses an inhibitor of bone morphogenetic protein signaling, noggin, but the role of noggin in ischemic disease outcome has not been studied. METHODS We used transgenic mice overexpressing noggin to assess whether...

Objective The presence of different missense mutations in sheep breeds have shown that the bone morphogenetic protein receptor 1B (BMPR1B), bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) genes play a vital role in ovulation rate and prolificacy in ewes. Therefore, the present study investigates BMPR1B, BMP15 and GDF9 genes mutations in prolific ewes of Iranian ...

The bone morphogenetic proteins (BMPs) are secreted polypeptides of the TGF-beta family, whose diverse functions include primary neural induction and the dorsoventral patterning of the neural tube. In this issue of Neuron, Aberle et al. (2002) and Marqués et al. present evidence that BMP receptors may also influence the development of synapses. The results suggest a novel mechanism for regulati...

Bone morphogenetic proteins (BMPs) belong to the TGF-β family, whose 33 members regulate multiple aspects of morphogenesis. TGF-β family members are secreted as procomplexes containing a small growth factor dimer associated with two larger prodomains. As isolated procomplexes, some members are latent, whereas most are active; what determines these differences is unknown. Here, studies on pro-BM...

New biological activities of bone morphogenetic proteins (BMPs) in the endocrine system have recently been revealed. The BMP system is composed of approximately 30 ligands and preferential combinations of type I and type II receptors. The BMP system not only induces bone formation but also plays unique tissue-specific roles in various organs. For instance, the ovarian BMP system is a physiologi...

Biocompatibility and osteoconductivity of porous scaffolds can be improved through coating technique by creating micro- nanostructures on the surfaces. In this study, a biomimetic approach was used to construct bone morphogenetic protein-2 (BMP-2) integrated calcium phosphate (CaP) surface titanium scaffolds. vitro characterizations showed that had mechanical properties comparable those human c...

Objective: To explore the mechanism of circRNA-vgll3 in osteogenic differentiation human bone marrow mesenchymal stem cells. Methods: BMSCs cells were transfected with circRNA-vgll3, and divided into high-level group, low-level negative control group (circRNA-vgll3 not transfected) according to amount transfection. The proliferation apoptosis osteoblasts each analyzed, alkaline phosphatase (ALP...