multipotent mesenchymal stromal cells or mesenchymal stem cells (mscs) are mainly isolated from bone marrow or fat tissue. because of their potential of multilineage differentiation towards bone, cartilage and fat tissue, they were initially evaluated to develop innovative strategies for tissue engineering applications. more recently, they have gained interest based on their immunomodulatory pr...

Biomineralization Article 2200976 by Luiz E. Bertassoni and co-workers presents injectable cell-laden bone-like tissue constructs that show promise as minimally invasive growth factor-free alternatives to bone autografts for repair regeneration of critical sized defects. By approximating the cellular, structural, chemical composition native bone, engineered microconstructs promote native-like m...

Human mesenchymal stem cells (hMSCs), which also called mesenchymal stromal cells, are multipotent stem cell. Human MSCs typically are positive for the surface markers CD44, CD73, CD90, CD105, CD106, and also negative for hematopoietic markers CD34 and CD45.These cells can be isolated from postnatal bone marrow, adipose tissue, placenta, and scalp tissue, as well as from various fetal tissues. ...

Bone fractures usually happen during car accident and sport trauma. Different factors influence bone healing such as malnutrition and smoking. Apart from addiction which is an important individual, social, and cultural problems morphine has several effects on body physiology and immune system .This study is performed to assess the effect of morphine dependency on bone healing and has not been r...

this study aimed to explore and validate a new juvenile osteopenic (jo) rat model then examine the efficacy of moghat (glossostemon bruguieri) as an alternative reversal therapy for jo. phytochemical screening analysis showed that moghat contains 5.8% alkaloids, 1.5% flavonoids and 13.2% total phenols. juvenile osteopenia was induced in 15 days old sprague- dawley female rats by feeding them fr...

Introduction: Osteoporosis is a bone disease in which there is a reduction in the amount of bone mineral content leading to an increase in the risk of bone fractures. The affected individuals not only have to go through lots of pain and suffering but this disease also results in high economic costs to the society due to a large number of fractures.  A timely and accurate diagnosis of this disea...

background: ligament reconstruction is a common procedure in orthopedic surgery. although several popular techniques are currently in use, new methods are proposed for secure fixation of the tendon graft into the bone tunnel. purposes: we sought to introduce our new technique of bashti bone plug for fixation of soft tissue graft in anterior cruciate ligament (acl) reconstruction and to compare ...

Objective(s): Autologous bone transplantation known as the “gold standard” to reconstruction of osseous defects has known disadvantages. This study was designed to explore the effects of hydroxy-apatite/tricalcium-phosphate (HA/TCP) and platelet-rich plasma (PRP) on the osteogenesis ability of human adipose-derived mesenchymal stem cells (hAdMSCs) in vitro and in vivo. Materials and Methods: hA...

Osteoporosis means 'Porous bone' is a disease characterized by progressive bone thinning. The deterioration of tissue can lead to fragility and fracture, especially the hip, spine, shoulder wrist. decreasing mineral density (BMD). Bisphosphonates are most commonly prescribed drugs for treatment osteoporosis in US many other countries including India.