Neuropeptide Y (NPY), the most abundant peptide in mammalian CNS, has been shown to inhibit excitatory neurotransmission presynaptically at the stratum radiatum-CA1 synapse in the in vitro rat hippocampal slice. We examined the site and mechanism of this inhibition in a series of in vitro intraand extracellular recordings in areas CA1 and CA3, the source of much of the excitatory synaptic input...

The objective of this work is to study the elimination Methyl Orange (MO) contained in wastewater, by adsorption on four different adsorbents, produced from peanut shells. To achieve this, various adsorbents were first produced. native biosorbent (BN) was obtained drying, crushing and sieving activated (BA) chemical activation with ortho-phosphoric acid (H3PO4) 10% BN. car...

Global cerebral ischemia (GCI) leads to inflammation and neuronal death in CA1. Curcumin with neuroprotective and anti-inflammatory properties is a potential candidate for suppressing cell death. The aim of this study was to determine the effects of curcumin on neuronal number in the CA1 area following GCI. 28 Sprague-Dawley male rats were randomly assigned into four groups including sham, cont...

We studied the pyramidal neurons of hippocampus in neonatal, juvenile and adult rats with hydrocephalus varying durations related these changes to their learning memory. Hydrocephalus was induced 7-day-old neonates, 4-week-old 16-week-old Albino by intra-cisternal injection 0.02-0.04 ml 150mg/ml kaolin sterile water (150 mg/ml). escape latency platform crossings Morris maze prior animal sacrifi...

Antagonism of the chloride-cotransport system in hippocampal slices has been shown to block spontaneous epileptiform (i.e., hypersynchronized) discharges without diminishing excitatory synaptic transmission. Here we test the hypotheses that chloride-cotransport blockade, with furosemide or low-chloride (low-[Cl(-)](o)) medium, desynchronizes the firing activity of neuronal populations and that ...

The hippocampus has differentiated into an extensively connected recurrent stage (CA3) followed by a feed-forward stage (CA1). We examined the function of this structural differentiation by determining how cell ensembles in rat CA3 and CA1 generate representations of rooms with common spatial elements. In CA3, distinct subsets of pyramidal cells were activated in each room, regardless of the si...

A series of Ca1–xSrxS:Eu (x = 0.0, 0.2, 0.4, 0.6, 0.8, 1.0) phosphors were synthesized by solid-state reactions. The Ca1–xSrxS:Eu phosphors have a strong absorption at 455 nm, which corresponds to the emission wavelength of a blue LED. The emission peak of Ca1–xSrxS:Eu is blue shifted from 655 to 618 nm with increasing Sr content. The characteristics of Ca1–xSrxS:Eu phosphors make them suitable...

We have produced a mouse strain in which the deletion of the NMDAR1 gene is restricted to the CA1 pyramidal cells of the hippocampus by using a new and general method that allows CA1-restricted gene knockout. The mutant mice grow into adulthood without obvious abnormalities. Adult mice lack NMDA receptor-mediated synaptic currents and long-term potentiation in the CA1 synapses and exhibit impai...

Results In the ischemia-operated-group, a significant loss of neurons was observed in the stratum pyramidale (SP) of the hippocampal CA1 region (CA1) at 5 days postischemia; however, in the IPC+ischemia-operated-group, neurons in the SP were well protected. In the immunohistochemical study, immunoreactivities of GK and GKRP in neurons of the SP were distinctively decreased in the CA1, not CA2/3...