Cancer has been, from the beginning, a target of intense research for gene therapy approaches. Currently, more than 60% of all on-going clinical gene therapy trials worldwide are targeting cancer. Indeed, there is a clear unmet medical need for novel therapies. This is further urged by the fact that current conventional cancer therapies are frequently troubled by their toxicities. Different gen...

Lung cancer remains the leading cause of cancer-related deaths both in Russia and worldwide, it is often diagnosed at a late stage median survival with traditional first-line chemotherapy platinum-based regimens does not exceed one year. The discovery activating mutations epidermal growth factor receptor ( EGFR ) gene offered first opportunity for personalized treatment advanced non-small cell ...

A growing area of research is focused on cancer therapy, and new therapeutic approaches are welcomed. Mesenchymal stem cell (MSC)-based gene therapy is a promising strategy in oncology. Intrinsic tropism and migration to tumor microenvironment with off lights are attractive features of this type of cell carrier. In this way, suicide genes have also found a good platform for better performance a...

Introduction Li–Fraumeni syndrome, an autosomal dominant cancer predisposition syndrome caused by a pathogenic variant of TP53, tumor suppressor gene, leads to high risk from early childhood developing various types cancers. Here, we report case advanced ureteral in syndrome. Case presentation A 73 years-old female patient, who had been diagnosed genetically as syndrome; suffered chondrosarcoma...

mucopolysaccharidoses are a group of rare mostly autosomal recessive metabolic and genetic disorders. because of the high rate of consanguinity, they are not uncommon in our population. clinical diagnosis is not difficult for experienced physicians, but it is not enough for treatment and prevention measures in the future pregnancies. so, it is necessary to detect the type of mps by measurement ...

The DNA damage response (DDR) is critical for maintaining genome stability, and abnormal DDR—resulting from mutations in damage-sensing repair proteins—is a hallmark of cancer. Here, we aimed to investigate the predictive power DDR gene tumor mutational load (TML) survival outcomes cohort 22 rectal cancer patients who received pre-operative neoadjuvant therapy. Univariate analysis revealed that...

Xerostomia or feeling of dry mouth is the most common (80%) all complications radiotherapy for head and neck cancer. Besides well-known artificial saliva agents therapies stimulating production salivary gland regeneration, new methods comprise use vitamins C E, low-level laser therapy, hyperbaric oxygen therapy thyme honey. Recently, transplantation mesenchymal stem cells was reported to be suc...

Gene therapy and virotherapy are among the approaches currently used to treat malignant tumors. Gene therapy and virotherapy use a specific therapeutic gene that causes death in cancer cells. In early attempts at gene therapy, therapeutic genes were driven by ubiquitous promoters such as the CMV promoter, which induce non-specific toxicity to normal cells and tissues in addition to the cancer c...

background: autophagy suppression recently has been known to have a remarkable effect for cellular adjustment and viability in the final stages of cancer. on the other hand, autophagy has the potential effect in preventing many viruses from replication. beclin1 is the most substantial constituent in autophagy apparatus regulation. this study was intended to investigate the beclin1 sirna knockdo...