background: several epidemiological studies conducted on underground miner’s show that exposure to elevated levels of radioactive radon gas is expected to increase the risk of lung cancer. relative risk of lung cancer is almost linear with radon exposure. elevated concentrations of radon are not only reported within mines but also for closed indoor environment of general public houses. measurem...

bladder cancer is the most frequent genitourinary malignancy in iran. environmental and genetic factors are the two factors linked with bladder cancer expansion. the aim of this study was to investigate the role of pten gene and environmental risk factors on the progression and prognosis of bladder cancer.we evaluated 55 tumor specimens and 66 bladder mucosa samples of non-cancerous patients be...

Background: Breast cancer is one of the most common diseases in women and causes more deaths rather than other cancers. The increasing trend of breast cancer in Iran makes clear the need of extensive breast cancer research in this area. Some studies showed that in the variety countries and even in the different areas in one country has different risk of breast cancer incidence and this is a rea...

To establish a comprehensive picture of the relationship between glutathione S-transferase omega 2 (GSTO2; MIM: 612314) gene N142D variant (rs. 156697) and breast cancer risk, the present meta-analysis was carried out. Studies published up to July 2012 with information about GSTO2 polymorphism and breast cancer risk were identified using several electronic databases. We identified 4 eligible st...

background : migrant studies offer a unique opportunity to analyze variation in disease occurrence due to background factors. the role of environmental and lifestyle exposures are of particular interest in cancer research, and migrant studies can be considered as natural experiments in epidemiological research. large numbers of immigrants from different regions of the world and the availability...

naturally occurring radionuclide of terrestrial origin (also called primordial radionuclide) are present in various degrees in all media in the environment, including the human body itself. their concentrations in environment decrease continually by decaying. the main objective of this study is to evaluate the radioactivity levels and health risks due to terrestrial radionuclide in soil of yal...

conclusions our study revealed that patients with the diagnosis of breast cancer have greater bpe in comparison with control group. the results may be indicative for higher probability of developing breast cancer in patients with higher bpe. therefore, ce-mri could be a useful tool for breast cancer risk assessment. objectives background parenchymal enhancement (bpe) on contrast-enhanced magnet...

Background: Venous thromboembolism (VTE) is a significant complication in cancer patients which was found in 4-20% of the patients. This study was aimed to evaluate risk factors of deep vein thrombosis (DVT) in cancer patients in an oncology center in Indonesia.  Methods: This was a retrospective cohort study. Data were obtained from medical records of adult cancer patients with DVT referring ...

Background and Objective: Mesenchymal stem cells (MSCs) promote metastasis in colorectal cancer; however, the mechanism underlying this process is not fully understood. Epithelial to mesenchymal transition (EMT) is a key step in tumor acquisition of metastatic phenotype. We aimed to investigate the effect of MSCs on the expression of EMT markers, as well as cancer stem cell markers in HT-29 col...

materials and methods twelve natural compounds jaceosidin, withaferin a, curcumin, epigallocatechin-3-gallate (egcg), artemisinin, gingerol, ursolic acid, ferulic acid, berberin, silymarin, resveratrol, and indol-3-carbinol were docked against e6 and e7 oncoproteins of high-risk hpv types 16 and 18 using a protein-ligand docking software called autodock4.2. results out of these 12 natural compo...