Immunotherapy with genetically engineered T-cells that express the chimeric antigen receptor (CAR) has raised hopes for the treatment of pediatric malignancies. Although CAR T-cell development is on a fast-moving pace and evolution, the context of exploring novel targetable antigens has been neglected. In this review study, we analyze the prominent hematologic antigens targeted by engineered T-...

In this paper, we study qualitative behaviour of trajectories of solutions of perturbed autonomous differential equations in the plane. We work in the framework of an axiomatic theory of solution spaces of ordinary differential equations suggested by V. V. Filippov (see the survey [7] and the references therein). This theory provides a unified approach to the study of solutions of ordinary diff...

Car following process is time-varying in essence, due to the involvement of human actions. This paper develops an adaptive technique for car following modeling in a traffic flow. The proposed technique includes an online fuzzy neural network (OFNN) which is able to adapt its rule-consequent parameters to the time-varying processes. The proposed OFNN is first trained by an growing binary tree le...

The automotive industry has pioneered the large scale use of robots. Long production runs of identical car bodies were the ideal field of application for early industrial robots, and spot welding lines with hundreds of robots have become a familiar sight. However, a lot of the production equipment is still based on hard automation. Today’s market is increasingly putting automobile manufacturers...

Railway system is composed of many sub-systems such as overhead contact lines, vehicles, tracks and structures, which interact with each other show complex dynamic behaviors. We are working on the elucidation countermeasures for railway-specific phenomena caused by interaction sub-systems, damage due to natural disasters, train running safety, deterioration using our own simulation experiment/m...

The recent tendency to reduce the weight of car bodies is posing a new challenge vertical ride quality, since vibrations related car-body bending modes affect heavily passengers’ comfort and cannot be fully mitigated by conventional vehicle suspensions. In this work, four mechatronic suspensions, considering active semi-active technologies in secondary primary are compared show their relative m...

In this contribution, investigations on model order reduction for coupled systems composed from components of a passenger car are shown. today's development processes, the simulation mechanical is indispensable and large Finite Element models often used purpose. For calculation time-domain or frequency-domain analyses, example, lot computing power required. However, with application methods, ef...