The C-C bond formation is an important reaction in organic synthesis to obtain value-added intermediates. Therefore, in this paper an attempt has been made to accelerate the Henry reaction (C-C bond formation) between aryl aldehydes and nitromethane using less expensive whole cell biocatalyst, baker’s yeast (BY). The scope of the methodology was also tested for the heteryl aldehyde i.e. 2-chlor...

objective: recent evidences suggest that tumors arise from a small subpopulation of cells, the cancer stem cells (cscs) or tumor initiating cells. cscs are able to resist the conventional methods of cancer therapy due to existence of abc transporters on their surface. this leads to csc resistance and maintenance resulting in post-treatment relapse and metastasis. therefore, precise identificati...

A Sigma factor gene which is important in the global regulation of heat shock responses in prokaryotes, rpoH, was isolated from Flexibacter chinesis by PCR, sequenced and compared to the rpoH genes of a variety of other organisms. The rpoH gene was 98% similar to other previously characterized genes. A mutant of rpoH was produced (JR102) which had a reduced growth rate at both low and high temp...

Nowadays, with the increasing pressure of the competitive business environment and demand for diverse products, manufacturers are force to seek for solutions that reduce production costs and rise product quality. Cellular manufacturing system (CMS), as a means to this end, has been a point of attraction to both researchers and practitioners. Limitations of cell formation problem (CFP), as one o...

isolated rat hepatocytes in culture were incubated with different concentrations of iron-sorbitol (50, 100, 150, and 200 µm) to assess the changes in reactive oxygen species (ros) and lipid peroxidation leading to apoptotic hepatocyte cell death. the viability of hepatocytes was declined depending on the iron concentration. one hour incubation of the cells with 100 µm iron resulted in decreased...

background a potential treatment for healing hepatic tissue is delivering isolated hepatic cells to the site of injury to promote hepatic cells formation. in this technology, providing an appropriate injectable system for delivery of hepatic cells is an important issue. in this regard, fibrin scaffolds were designed with many advantages over other scaffolds like cell delivery vehicles for biode...

Thioridazine (TZ) is used mainly in the treatment of schizophrenia. However, hepatotoxicity as a life-threatening adverse effect is associated with its clinical use. In this context, we examined the cytotoxic mechanisms of TZ on freshly isolated rat hepatocytes to better understanding of the pathogenesis of TZ-induced hepatotoxicity. Hepatocytes were prepared by the method of collagenase enzyme...

adenoid ameloblastoma with dentinoid is a rare odontogenic tumor. granular cell ameloblastoma also is a less common histological subtype of ameloblastoma. in this report, the patient was a 31‑year‑old male. the lesion was located in the right mandible and was unicystic with well‑defined borders. the tumor tissue was showing a combination of follicular, plexiform, and desmoplastic patterns of am...