objective(s): t-cell acute lymphoblastic leukemia (t-all) is an aggressive hematologic malignant tumor. administration of chemical compounds influencing apoptosis and t cell development has been discussed as promising novel therapeutic strategies. valproic acid (vpa) as a recently emerged anti-neoplastic histone deacetylase (hdac) inhibitor and pioglitazone (pgz) as a high-affinity peroxisome p...

Background and Aims:In neurodegenerative disorders,oxidative stress mediated by reactive oxygen species is strongly associated with increased neuronal damages which can lead to apoptosis. Pro-apoptotic and anti-apoptotic gene expressions are changed during the cell differentiation that affect cell viability and differentiation. Therefore, this study was conducted to determine the effects of hyd...

Abstract Our current understanding of pathways governing the strength and longevity T cell mediated immune responses primarily focuses on transcriptional epigenetic changes. However, our prior work demonstrated that optimal effector function is also dependent RNA binding proteins (RBPs) carry out post-transcriptional splicing polyadenylation. Here, we find a specific family RBPs, serine- argini...

cellular and molecular pathways link thrombosis and innate immune system during sepsis. extrinsic pathway activation of protease thrombin through fviia and tissue factor (tf) in sepsis help activate its endothelial cell (ec) membrane protease activated receptor 1 (par-1). thrombin adjusts the ec cycle through activation of g proteins (g12/13), and later through rho gefs (guanine nucleotide exch...

Exosomes play a crucial role in the crosstalk between cancer associated fibroblasts (CAFs) and cells, contributing to carcinogenesis tumour microenvironment. Recent studies have revealed that CAFs, normal cells all secrete exosomes contain miRNA, establishing cell-cell communication network within For example, miRNA dysregulation melanoma has been shown promote CAF activation via induction of e...

Bakground: Multiple sclerosis (MS) is a CD4+ T cell-mediated autoimmune disease affecting the central nervous system (CNS). It was previously believed that Th1 cells were pathogenic T cells in experimental autoimmune encephalomyelitis (EAE). However, the functional role of Th1 cells in EAE has been reconsidered upon the discovery of IL-17- producing T cells which are consider as dominant effect...