Drugs used to treat brain or central nervous system disorder suffer from shortfall of absorption and reaching brain due to blood brain barrier and cerebro spinal fluid barrier. Intra nasal administration of brain targeted drug delivery system is gaining popularity to circumvent blood brain barrier and enhance drug availability in brain. It also shows promising reduction of systemic adverse effe...

Eosinophilic peritonitis is defined as when there are more than 100 eosinophils present per milliliter of peritoneal effluent, of which eosinophils constitute more than 10% of its total WBC count. Most cases occur within the first 4 weeks of peritoneal catheter insertion and they usually have a benign and self-limited course. We report a patient of eosinophilic peritonitis that was successfully...

Peripheral arterial disease (PAD) is caused by atherosclerosis and is associated with microcirculatory impairments in skeletal muscle. The present study evaluated the angiogenic response to exercise and passive movement in skeletal muscle of PAD patients compared with healthy control subjects. Twenty-one PAD patients and 17 aged control subjects were randomly assigned to either a passive moveme...

background and objectives: preterm labor is a serious problem in obstetrics, accounting for 70% of perinatal mortality. high sensitive c - reactive protein (hs-crp) is a sensitive marker of inflammation. our aim in this study was to determine amniotic fluid hs-crp concentration and its correlation with pre-term delivery.   materials and methods: this prospective study was conducted on 90 pregna...

objective: to investigate the clinical advantage of several prognostic factors for predicting preterm delivery. materials and methods: eighty and six patients with a singleton pregnancy admitted to vali-asr hospital underwent genetic amniocentesis between the 15th and 23th weeks were included in this study. maternal serum c-reactive protein (crp), transvaginal sonographic measurement of cervica...

Accessible online at: www.karger.com/journals/nef Dear Sir, Peritonitis is a common complication in patients with end-stage renal disease treated by continuous ambulatory peritoneal dialysis (CAPD). It is usually caused by poor technique, exit-site infection [1, 2], tunnel infection [3, 4], perforation of hollow viscera [5], diverticulitis [6, 7], colitis [8], or cholecystitis [9], etc. It is u...

Standard microbiological tests (i.e., MIC) do not account for the unique factors of peritoneal dialysis (PD)-related peritonitis which can significantly influence treatment response. Our goals were to develop a peritoneal fluid titer (PFT) test and to conduct a pilot study of its association with clinical outcome. The methodology was developed by using spent dialysate collected from patients wi...

the objective of present research was to design, evaluate and compare drug release from two different dosage forms in pulsatile drug delivery system (dds) for metoprolol tartarate (mt) as tablet and capsule. pulsatile systems are gaining a lot of interest as they deliver the drug at the right site of action at the right time and in the right amount, thus providing spatial and temporal delivery ...

Micro-sorbent traps referred to as microtraps serve as integrated concentration-injection devices for continuous monitoring in gas phase streams. The application of carbon nanotubes as unique sorbents for the fabrication of microtraps for the nano-scale adsorption/desorption of volatile organic molecules is presented in this paper. The microtrap application requires high adsorption capacity as ...