(-)-gephyrotoxin-223 was formally synthesized from chiral synthon 1 which has been chemoenzymatically synthesized  in the presence  of candida antartica lipase.

Chiral magnetic skyrmions are topological solitons, of significant physical interest, arising in ferromagnets described by a micromagnetic energy including chiral (Dzyaloshinskii-Moriya) interaction term. We show that for small interaction, the on R 2 with co-rotational symmetry close to harmonic maps, and prove precise bounds differences. One application these is asymptotics. Another (pursued ...

Strecker reaction is one of the simplest multicomponent reactions. It used for synthesis of chiral α-amino nitriles. This reaction was carried out in the presence of catalytic amount of layered double hydroxides (LDHs). In this study, simple and practical method for the synthesis of this class of catalysts is provided. The results shown that LDH is the good heterogen catalyst for synthesis of c...

The high performance liquid chromatography (HPLC) enantioseparation of four β-blocking agents metoprolol, bisoprolol, propranolol and atenolol was performed on amylose tris-(3,5-dimethylphenylcarbamate) chiral stationary phase using n-hexane-ethanol-diethylamine (DEA) as the mobile phase and related chiral recognition mechanisms were discussed. Enantiomeric separation of the fourβ-blockers was ...

Modafinil [2-[(diphenylmethyl)sulfinyl]acetamide] is used clinically in the treatment of narcolepsy and sleeping disorders. The synthesis of modafinil, begins with the reaction of benzhydrol and thioglycolic acid in trifluoroacetic acid to afford benzhydrylsulfinyl acetic acid. The reaction of acid with thionyl chloride in benzene followed by treatment with ammonium hydroxide gave acetamide...

The present study describes a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous determination of S-RRR and R-SSS nebivolol (nebivolol enantiomers) in human plasma using solid phase extraction technique. Method of both S-RRR and R-SSS nebivolol (nebivolol enantiomers) has been developed and validated using racemic nebivolol D4 as an internal standard. Analytes...

Dynamics of SU(Nc) Yang–Mills theories with Nf adjoint Weyl fermions is quite different from that of SU(Nc) gauge theories with fundamental quarks. The symmetry breaking pattern is SU(Nf ) → SO(Nf ). The corresponding sigma model supports Skyrmions whose microscopic identification is not immediately clear. We address this issue as well as the issue of the Skyrmion stability. The case of Nf = 2 ...