Among people at genetic risk of schizophrenia, those who use cannabis show smaller thalamic and hippocampal volumes. We evaluated this relationship in people at clinical high risk (CHR) of psychosis. The Alcohol and Drug Use Scale was used to identify 132 CHR cannabis users, the majority of whom were non-dependent cannabis users, 387 CHR non-users, and 204 healthy control non-users, and all par...

The rule-based programming language Constraint Handling Rules (CHR) has been introduced to ease the development and implementation of constraint solvers. Currently, several CHR libraries exist in languages such as Prolog, Haskell and Java. The K.U.Leuven JCHR system is a high-performance integration of Constraint Handling Rules (CHR) and Java. JCHR is currently by far the most efficient impleme...

Constraint Handling Rules (CHR) is an elegant, high-level programming language based on multi-headed, forward chaining rules. To ensure CHR propagation rules are applied at most once with the same combination of constraints, CHR implementations maintain a socalled propagation history. The performance impact of this history can be significant. We introduce several optimizations that, for the maj...

A proportion of gastrinomas demonstrates aggressive growth, and most deaths occur in this group. Little is known about the molecular pathogenesis of growth of this tumor, and there are no predictive factors that are useful in an individual patient. Chromosome 1 (Chr 1) loss of heterozygosity (LOH) is frequent in a number of nonendocrine tumors and in a few endocrine tumors, and its presence can...

Both viral and host genetics affect the outcome of herpes simplex virus type 1 (HSV-1) infection in humans and experimental models. Little is known about specific host gene variants and molecular networks that influence herpetic disease progression, severity, and episodic reactivation. To identify such host gene variants we have initiated a forward genetic analysis using the expanded family of ...

This article has not been copyedited and formatted. The final version may differ from this version. ABSTRACT The ontogeny of the first four families of cytochrome P450s (Cyp1-4) can affect the biotransformation of drugs and dietary chemicals in liver resulting in unique pharmacological reactions in children. As genome-scale investigations have identified many novel Cyp isoforms recently, it is ...

This paper proposes an integration of Constraint Handling Rules (CHR), a rulebased language to specify application-oriented constraint solvers, into the declarative multiparadigm language Curry. This integration provides a convenient way to specify and use flexible constraint systems in applications implemented in Curry. We propose to represent CHR as data objects in Curry programs so that the ...

Adaptive constraint processing with Constraint Handling Rules (CHR) allows the application of intelligent search strategies to solve Constraint Satisfaction Problems (CSP), but these search algorithms have to be implemented in the host language of adaptive CHR, which is currently Java. On the other hand, CHR enables to explicitly formulate search in CHR, using disjunctive bodies to model choice...

Constraint Handling Rules (CHR) is a very-high-level declarative programming language based on concurrent multiset rewrite rules that are conditional, multiheaded, and committed-choice. Originally designed in the early 1990s as a specialpurpose programming language for adding user-defined constraint solvers to a host language, CHR has evolved over the last decade into a powerful and elegant gen...