The Chinese Kunming (KM) mouse is a widely used outbred mouse stock in China. However, its genetic structure remains unclear. In this study, we sequenced the genome of the C57BL/6J-Chr1KM (B6-Chr1KM) strain, the chromosome 1 (Chr 1) of which was derived from one KM mouse. With 36.6× average coverage of the entire genome, 0.48 million single nucleotide polymorphisms (SNPs) and 96,679 indels were...

Mouse resources such as Collaborative Cross (CC), Outbred Stocks (OS), Hybrid Mouse Diversity Panel (HMDP), and Chromosome Substitution Strains (CSSs) have been instrumental to many progresses in the studies of complex traits genetics. We have established a population of chromosome 1 (Chr 1) substitution lines (C1SLs) in which donor chromosomes were derived from Chinese wild mice. Genome sequen...

weed pollen grains belonging to  the  asteraceae  family contain  a variety of  allergens inducing type i  and iv allergies in susceptible people. the  aim of this research was to compare  the  allergenic properties  of  immature  and  mature  shasta  daisy pollen  grains (chrysanthemum maximum ramond) to define the potential role of the maturation process on the allergenicity of asteraceae pol...

Chromomycin A3 (CHR) binding to the duplex d(CAAGTCTGGCCATCAGTC).d(GACTGATGGCCAGACTTG) has been studied using quantitative footprinting methods. Previous NMR studies indicated CHR binds as a dimer in the minor groove. Analysis of autoradiographic spot intensities derived from DNase I cleavage of the 18-mer in the presence of various amounts of CHR revealed that the drug binds as a dimer to the ...

Cell cycle-dependent gene expression is often controlled on the transcriptional level. Genes like cyclin B, CDC2 and CDC25C are regulated by cell cycle-dependent element (CDE) and cell cycle genes homology region (CHR) promoter elements mainly through repression in G(0)/G(1). It had been suggested that E2F4 binding to CDE sites is central to transcriptional regulation. However, some promoters a...

A relation between the multiplicity m of the second eigenvalue λ2 of a Laplacian on a graph G, tight mappings of G and a discrete analogue of Courant’s nodal line theorem is discussed. For a certain class of graphs, it is shown that the m-dimensional eigenspace of λ2 is tight and thus defines a tight mapping of G into an m-dimensional Euclidean space. The tightness of the mapping is shown to se...

A relation between the multiplicity m of the second eigenvalue λ2 of a Laplacian on a graph G, tight mappings of G and a discrete analogue of Courant’s nodal line theorem is discussed. For a certain class of graphs, it is shown that the m-dimensional eigenspace of λ2 is tight and thus defines a tight mapping of G into an m-dimensional Euclidean space. The tightness of the mapping is shown to se...

Herrera, Victoria L. M., Aristides Tsikoudakis, Lorenz R. B. Ponce, Yuichi Matsubara, and Nelson Ruiz-Opazo. Sex-specific QTLs and interacting loci underlie salt-sensitive hypertension and target organ complications in Dahl S/jr hypertensive rats. Physiol Genomics 26: 172–179, 2006. First published May 23, 2006; doi:10.1152/physiolgenomics.00285.2005.—Sex-specific differences in polygenic (esse...

OBJECTIVES Peptides derived from the C-terminal heptad repeat (CHR) of HIV-1 gp41 are potent fusion inhibitors. We have recently demonstrated that the unique M-T hook structure preceding the pocket-binding motif of CHR peptide-based inhibitors can greatly improve their antiviral activity. In this study, we applied the M-T hook structure to optimize sifuvirtide (SFT), a potent CHR-derived inhibi...