Background: Lymphocytes of Fanconi anemia (FA) show an increased sensitivity to the alkylating agents such as mitomycin C (MMC), but their responses to gamma-irradiation is controversial. The extent of DNA damage in leukocytes of FA patients following irradiation and MMC treatment was studied at cellular and single chromosome level. Methods: DNA damage induced by gamma-rays and MMC was measure...

introduction: the incidence of chromosomal abnormalities was investigated in untransfered embryos reuslted from in vitro fertilization (ivf) or intracytoplasmic sperm injection (icsi) procedures. materials and methods: a total of 238 embryos of varying morphology between the pronucleated stage and 8-cells were analysed. the cytogenetic method of dyban was used for chromosome preparation. embryo...

Protein tyrosine phosphatases (PTPases) regulate the tyrosine phosphorylation of target proteins in‌volved in several biological activities including cell proliferation and transformation. Protein tyrosine phosphatase E (PTPE) contains duplicated PTPase-like domains and a short extracellular region. Us‌ing the fluorescence in situ hybridization method, the gene encoding PTPE (locus symbol Ptpre...

erodium (geranaiceae) species are distributed in different habitats of iran. some species are of medicinal importance while some are well known weeds. there are no chromosome counts for erdoium species of iran. chromosome numbers are given for six taxa of erodium (geraniaceae) from iran: e. cicutarium (2n=36), e. ciconium(2n=18), e. malacoides (2n=20), e. moschatum (2n=20), e. neuradifolium (2n...

 Abstract  Background: Mosaic form of turner syndrome that represented by two or more  cell lines in an affected individual, often has limitation for detection with classical  cytogenetic methods. The present study was carried out to compare the efficiency of  interphase Fluorescence In Situ Hybridisation (FISH) and cytogenetic techniques in  detection of mosaic form of turner syndrome.  Method...

Background The androgen receptor (AR) gene contains a polymorphic trinucleotide repeat that encodes a polyglutamine tract in its N-terminal transactivation domain (NTAD). We aimed to find a correlation between the length of this polymorphic tract and azoospermia or oligozoospermia in infertile men living in Khuzestan, Iran. MaterialsAndMethods In this case-control study during two years till 20...