Invasive meningococcal disease (IMD) is a severe bacterial infectious disease with high mortality and morbidity rates worldwide. In recent years, industrialised countries have implemented vaccines targeting IMD in their National Immunisation Programmes (NIPs). In 2002, the Netherlands successfully implemented a single dose of meningococcal serogroup C conjugate vaccine at the age of 14 months a...

Encoding is a fundamental part of any EA. The solution encoding, and its interactions with the EA’s operators, should be designed to minimise arbitrary search bias. A multidimensional encoding suitable for fully specified fuzzy logic rulebases is investigated, and is shown to have better convergence than traditional single-dimensional encoding. By comparison with 2-point and uniform crossover, ...

This paper considers the set-point optimisation problem under plant-model mismatch. Three iterative optimisation strategies, the two-step method, the integrated system optimisation and parameter estimation (ISOPE) method and the gradientmodification optimisation method are compared for a nonlinear chromatographic separation process using different structurally mismatched models as nominal proce...

Background: An effective polymer gel dosimeter can be fabricated by varying the composition of its chemical components. Materials and Methods: The MAGAT gel dosimeter formulations that used different compositions of Methacrylic acid (MAA) and gelatin were extensively investigated in the present study according to the R2–dose response and R2–dose sensitivity. The irradiation of M...

Recently, a combination between simulation and optimisation has been important for many of HVAC design problems. Long execution time is usually needed for one simulation run; consequently huge time will be required for the optimisation process. The aim of this study is to evaluate how combinations between optimisation algorithms can achieve faster and/or better solutions for multiobjective opti...

In many application domains, optimisation and other analytic models are often embedded as a decision engine within the respective business processes. In this paper, we study recent trends in the provision of optimisation tools and optimisation-based decision support systems (DSS) as web-enabled distributed applications. We analyse the evolution from the Application Service Provision (ASP) model...

A method for automated synthesis of asynchronous circuits using direct mapping for control path and data path is presented. The idea of direct mapping is that a graph specification of a system is translated into a circuit netlist by mapping the graph nodes into circuit elements and the graph arcs into circuit interconnects. The key feature of this approach is its low algorithmic complexity and ...

In modern cars, an increasing number of functions are integrated in single control units. Some of the functions can be ordered as optional equipment by the customer. To reduce costs, variants of the control units are created differing in hardware and software. Variants are created by not populating sections of a circuit board. Each additional variant of a control unit causes expenses for logist...

OBANET project aims at designing and testing specific coverage area management strategies as well as their associated technologies for performance optimisation in broadband adaptive broadband wireless access networks in two scenarios: fixed and mobile broadband radio accesses in the 40 GHz band. Optically beamformed base station antennas capabilities to address dynamically changes in the networ...