Molecular farming has been considered as a secure and economical approach for production of biopharmaceuticals. Human TNF Related Apoptosis Inducing Ligand (TRAIL) as a promising biopharmaceutical candidate has been produced in different expression hosts. However, little attention has been paid to molecular farming of the TRAIL in spite of numerous advantages of plant expression systems. Theref...

background: bone marrow stromal stem cells (bmsc) are appropriate source of multipotent stem cells that are ideally suited for use in various cell-based therapies. it can be differentiated into neuronal-like cells under appropriate conditions. this study examined the effectiveness of co-stimulation of creatine and retinoic acid in increasing the differentiation of bmsc into gabaergic neuron-lik...

objective(s): tlr-4 activates a number of inflammatory signaling pathways. also, ampk could be involved in anti-inflammatory signaling. the aim of this study was to identify whether stimulation of ampk could inhibit lps-induced tlr-4 gene expression in mice hearts. materials and methods: heart ampk activity and/or tlr-4 expression was stimulated in different mice groups, using respectively ip i...

Immunohistochemical (IHC) analysis of tissue biopsies is currently used for clinical screening solid cancers to assess protein expression. The large amount image data produced from these samples requires specialized computational pathology methods perform integrative analysis. Even though proteins are traditionally studied independently, the study co-expression may offer new insights towards pa...

Molecular farming has been considered as a secure and economical approach for production of biopharmaceuticals. Human TNF Related Apoptosis Inducing Ligand (TRAIL) as a promising biopharmaceutical candidate has been produced in different expression hosts. However, little attention has been paid to molecular farming of the TRAIL in spite of numerous advantages of plant expression systems. Theref...

background :adenosine is an endogenous purine nucleoside that has a neuromodulatory role in the central nervous system. the amphetamine derivative (±)-3,4-methylenedioxymethamphetamine (mdma or ecstasy) is a synthetic amphetamine analogue used recreationally to obtain an enhanced affiliated emotional response. mdma is a potent monoaminergic neurotoxin with the potential of damage to brain neuro...