Introduction: The proteoglycans of the extracellular matrix increases in the glial scar during spinal cord injury and significantly affects the inhibition of axonal regeneration.  Methods: The results of injury therapies are limited due to the lack of identifying a timely therapeutic intervention. The present study aimed to investigate the glial scar Chondroitin Sulfate (CS) and Dermatan Sulfa...

OBJECTIVE To assess mature burn scars treated with a fractional carbon dioxide laser for changes in histological architecture, type I to III collagen ratios, density of elastic tissue, and subjective measures of clinical improvements. DESIGN Uncontrolled, prospective study of patients with mature burn scars, from a clinical and histological perspective. Biopsy specimens were obtained before a...

This review analyzes different scientific views on the diagnosis and treatment of chemical burns esophagus its consequences - formation cicatricial stenosis organ. Post-burn scar in pediatric surgery is a fairly common disease that formed children with burn 3rd degree. In study this pathology timely between degrees esophageal correct selection patients for dilatation organ particular interest p...

The article presents the experience of surgical treatment 172 patients with post-burn scar deformities and defects lower extremities. Based on results obtained, practical recommendations optimal choice methods operations are given.

OBJECT Matrix metalloproteinases (MMPs), particularly MMP-9/gelatinase B, promote early inflammation and barrier disruption after spinal cord injury (SCI). Early blockade of MMPs after injury provides neuroprotection and improves motor outcome. There is recent evidence, however, that MMP-9 and MMP-2/gelatinase A participate in later wound healing in the injured cord. The authors therefore exami...

Burn scars are known to be difficult to treat because of their tendency to worsen with hypertrophy and contracture. Various experimental and clinical efforts have been made to alleviate their effects but the problem has not been solved. Since patients keep asking for Low Level Laser Therapy (LLLT) and believe in its effectiveness on burn scars, and since former studies show contradictory result...

Burn care has an important role in the history of Plastic Surgery; requirements of burn and scar treatment have formed the basis of the development of most of the techniques that constitute Plastic Surgery core knowledge. While deeper understanding of burns physiology helped greatly to reduce mortality and improve outcomes in the acute burn phase, scar revision and postoperative management are ...

the prevalence of spinal cord injury (sci) is about 2.5 million in the worldwide and more than 130,000 new injuries reported each year. regeneration in the cns versus the pns is very different from the other tissues and many factors can prevent regeneration in pns and specially cns. previous researches demonstrated that regeneration of cns can inhibit by inhibitory molecules and glial scar. the...

The mechanisms of hypertrophic scar formation are not fully understood. We previously screened the differentially expressed genes of human hypertrophic scar tissue and identified P311 gene as upregulated. As the activities of P311 in human fibroblast function are unknown, we examined the distribution of it and the effects of forced expression or silencing of expression of P311. P311 expression ...