نتایج جستجو برای: crescentic glomerulonephritis

تعداد نتایج: 12609  

Journal: :Journal of the American Society of Nephrology : JASN 2008
Richard K S Phoon A Richard Kitching Dragana Odobasic Lynelle K Jones Timothy J Semple Stephen R Holdsworth

T-bet is a transcription factor that is essential for T helper (Th)1 lineage commitment and optimal IFN-gamma production by CD4(+) T cells. We examined the role of T-bet in the development of experimental crescentic glomerulonephritis, which is induced by Th1-predominant, delayed-type hypersensitivity-like responses directed against a nephritogenic antigen. Anti-glomerular basement membrane (GB...

2012
Ryuji Morizane Konosuke Konishi Akinori Hashiguchi Hirobumi Tokuyama Shu Wakino Hiroshi Kawabe Matsuhiko Hayashi Koichi Hayashi Hiroshi Itoh

BACKGROUND Antineutrophil cytoplasmic antibody (ANCA)-associated crescentic glomerulonephritis (CGN) is a major cause of rapidly progressive glomerulonephritis (RPGN). ANCA-associated CGN is generally classified into pauci-immune RPGN, in which there are few or no immune complexes. CASE PRESENTATION A 78-year-old man presented with RPGN after a 7-year course of chronic proteinuria and hematur...

Journal: :Journal of the American Society of Nephrology : JASN 2010
Jacques Behmoaras Jennifer Smith Zelpha D'Souza Gurjeet Bhangal Ratana Chawanasuntoropoj Frederick W K Tam Charles D Pusey Timothy J Aitman H Terence Cook

The Wistar Kyoto (WKY) rat is uniquely susceptible to experimentally induced crescentic glomerulonephritis. Two major quantitative trait loci (QTLs) on chromosomes 13 (Crgn1) and 16 (Crgn2) with logarithm of odds >8, as well as five other loci (Crgn3 through 7), largely explain this genetic susceptibility. To understand further the effects of Crgn1 and Crgn2, we generated a double-congenic stra...

Journal: :Internal medicine 1998
S Takeda H Kida H Yokoyama E Takazakura K Kobayashi

To clarify the effectiveness of methylprednisolone pulse therapy on crescentic glomerulonephritis (CresGN), data of 46 patients was retrospectively studied. According to the slope of reciprocals of serum creatinine (s-Cr) the patients were divided into acute and insidious types, and each type was further divided into pulse (P) and conventional (C) therapy groups. In group C, s-Cr improved more ...

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