Renal involvement especially glomerulonephropathy in polymyositis or dermatomyositis is considered rare. Crescentic glomerulonephritis is even more so. Herein, we report a patient who was diagnosed with concurrent polymyositis and myeloperoxidase-related crescentic glomerulonephritis. We discuss the association between polymyositis or dermatomyositis and renal involvement, glomerulonephropathy,...

As a means of studying mechanisms of response to injury in glomerulonephritis, glomeruli from normal sheep and rabbits and from sheep and rabbits with experimental crescentic glomerulonephritis have been isolated and grown in tissue culture. The cellular outgrowths from the normal and diseased glomeruli have been compared. The outgrowth of glomeruli from normal animals contained only two cell p...

Crescentic glomerulonephritis is characterized by extracapillary proliferation resulting from severe inflammatory injury of various aetiologies. It is usually rapidly progressive. Meanwhile, anti-glomerular basement membrane (GBM) antibody-mediated glomerular lesions induce crescentic glomerulonephritis. When associated with pulmonary haemorrhage, it is given the eponym 'Goodpasture's syndrome'...

Cellular lesions form in Bowman's space in both crescentic glomerulonephritis and collapsing glomerulopathy. The pathomechanism and origin of the proliferating cells in these lesions are unknown. In this study, we examined proliferating cells by lineage tracing of either podocytes or parietal epithelial cells (PECs) in the nephrotoxic nephritis model of inflammatory crescentic glomerulonephriti...

We report a case of a 71-year-old man with rapidly progressive nephritic syndrome and dual positivity for anti-glomerular basement membrane antibody and myeloperoxidase-specific anti-neutrophil cytoplasmic antibody. Renal biopsy revealed crescentic, mainly cellular, glomerulonephritis with granulomatous lesions, and advanced membranous changes. Membranous nephropathy had apparently existed for ...

Features of crescentic glomerulonephritis suggest that it results from a T helper 1 (Th1) nephritogenic immune response. Interferon-gamma (IFN-gamma), produced by Th1 cells, is involved in T cell-directed macrophage activation in effector Th1 responses. The hypothesis that endogenous IFN-gamma contributes to the development of crescentic glomerulonephritis was tested by comparing the developmen...

conclusions the occurrence of sam in pauci-autoimmune vasculitis is rarely described, particularly in africa. our case is an illustration of the reality of this association. introduction we reported a case of hemophagocytic syndrome complicating microscopic polyangitis presented by crescentic glomerulonephritis. case presentation a 22-year-old female patient originated from dakar, senegal prese...

Although various glomerular diseases in hantavirus infection have been reported, an association between hantavirus infection and crescentic glomerulonephritis has not been described. Herein, we report a case of immune complex-mediated crescentic glomerulonephritis in a 70-year-old man with Hantaan virus infection.

Anti-glomerular basement membrane (anti-GBM) disease is characterized by crescentic glomerulonephritis with immunoglobulin G (IgG) autoantibodies to the non-collagenous (NC1) domain of α3(IV) collagen presenting along the GBM. The patient clinically manifests with rapidly progressive glomerulonephritis (RPGN) with pulmonary hemorrhage (Goodpasture...