PURPOSE The purpose of this study is to systematically identify and review articles that use the case-crossover study design in the area of pharmacoepidemiology. METHODS A systematic search of MEDLINE® (Ovid Technologies, New York City, NY, USA), EMBASE® (Elsevier Inc., Philadelphia, PA, USA), and Web of Science® (Thomson Reuters, New York City, NY, USA) was completed to identify all English ...

When Genetic Algorithms are employed in multimodal function optimization, identifying multiple peaks and maintaining subpopulations of the search space are two central themes. In this paper, we use an immune system model to explore the role of crossover in GAs with respect to these two issues. The experimental results reported here will shed more light into how crossover affects the GA’s search...

OBJECTIVE To evaluate the benefit of a health information exchange (HIE) between hospitals, we examine the rate of crossover among neurosurgical inpatients treated at Emory University Hospital (EUH) and Grady Memorial Hospital (GMH) in Atlanta, Georgia. To inform decisions regarding investment in HIE, we develop a methodology analyzing crossover behavior for application to larger more general p...

This paper studies the nonlinear optimization problems subject to bipolar max-min fuzzy relation equation constraints. The feasible solution set of the problems is non-convex, in a general case. Therefore, conventional nonlinear optimization methods cannot be ideal for resolution of such problems. Hence, a Genetic Algorithm (GA) is proposed to find their optimal solution. This algorithm uses th...

OBJECTIVE To test the verbal memory of older volunteers given citicoline. DESIGN A randomized, double-blind, placebo-controlled, parallel group design was employed in the initial study. After data analysis, a subgroup was identified whose members had relatively inefficient memories. These subjects were recruited for a second study that used a crossover design. The subjects took either placebo...

DNA origami and single-stranded tile (SST) are two proven approaches to self-assemble finite-size complex DNA nanostructures. The construction elements appeared in structures from these two methods can also be found in multi-stranded DNA tiles such as double crossover tiles. Here we report the design and observation of four types of finite-size lattices with four different double crossover tile...

This work analyzes fitness landscapes for the image filter design problem approached using functional-level Cartesian Genetic Programming. Smoothness and ruggedness of fitness landscapes are investigated for five genetic operators. It is shown that the mutation operator and the single-point crossover operator generate the smoothest landscapes and thus they are useful for practical applications ...

The rational design of magnetic and fluorescent bifunctional materials is attracting increasing interest. In this study, two mononuclear Fe(ii) complexes, namely [Fe(L)2(NCS)2] (1) and [Fe(L)2(NCSe)2] (2) are synthesised by combining a spin-crossover unit and a fluorescent ligand (naphth-1-yl)-N-(3,5-di(pyridin-2-yl)-4H-1,2,4-triazol-4-yl)methanimine (L) to achieve bifunctionality. Single-cryst...