نتایج جستجو برای: d21
تعداد نتایج: 629 فیلتر نتایج به سال:
A Hypersweet Protein: Removal of The Specific Negative Charge at Asp21 Enhances Thaumatin Sweetness.
Thaumatin is an intensely sweet-tasting protein that elicits sweet taste at a concentration of 50 nM, a value 100,000 times larger than that of sucrose on a molar basis. Here we attempted to produce a protein with enhanced sweetness by removing negative charges on the interacting side of thaumatin with the taste receptor. We obtained a D21N mutant which, with a threshold value 31 nM is much swe...
Combination antiretroviral therapies (cART)can lead to normal life expectancy in HIV-infected persons, and people aged >50 yrs represent the fastest growing HIV group. Although HIV and aging are independently associated with impaired humoral immunity, immune status in people aging with HIV is relatively unexplored. In this study influenza vaccination was used to probe age associated perturbatio...
A principal owns a firm, hires an agent of uncertain productivity, and designs dynamic policy for evaluating his performance. The observes ongoing evaluations decides when to quit. When not quitting, the is paid wage that linear in expected productivity; claims residual After players secure fixed outside options. I show equilibrium Pareto efficient. For broad class performance technologies, det...
De la capacité de l’entrepreneur à concevoir une organisation apte créer des canaux d’information suffisamment robustes dépendent nature innovations effectuées, façon dont sont exploitées les connaissances scientifiques et techniques, l’usage qui est fait l’esprit créatif. C’est cette aune qu’il convient juger du comportement entrepreneurial, rythmes imposés par finance, allouées ressources hum...
الگوهای تعیین ساختار بازار اهمیتی بسیار حیاتی در نظریهپردازی و کارهای تجربی داشته و به همین علت طیف وسیعی از ادبیات اقتصاد خرد، اقتصاد صنعتی و اقتصاد کاربردی را شکل میدهد. در این مقاله با استفاده از تعیین محدودههای حدی در چهار نوع بازار رقابت کامل، رقابت انحصاری، انحصار چندجانبه و انحصار کامل برای شاخص هرفیندال، با استفاده از شبیهسازی عددی برای بنگاههای فرضی با سهمهای متفاوت از بازار، این...
رقابت ذیری از موضوعات اصلی و مهم در اقتصاد به شمار میرود که از آن بهعنوان ابزاری برای رشد مطلوب و توسعه پایدار یاد می شود. در این تحقیق رقابتپذیری صنایع مورد پذیرش در بورس اوراق بهادار تهران که بیشتر از 2 بنگاه در بازه زمانی 1395-1386 داشتهاند، مورد مطالعه قرار گرفته است. برای مطالعه رقابت پذیری تحرک معیارهای عملکرد فنی و عملکرد اقتصادی به دو روش مورد بررسی قرار گرفته اند. یکی منحنی سال...
Several aspects of bacterial glucose assimilation and bacterial production (BP) were investigated over 2 d in the upper 300 m of the Gulf of Mexico. Glucose concentrations ranged from 2 to 15 nM in surface seawater; glucose utilization rates were 1–3 nM d21 in the upper 150 m of the water column and 0.02–0.8 nM d21 in deeper water (150–300 m). Turnover of glucose and bacteria were similar and w...
We studied the role of photochemical and microbial processes in contributing to the transformation of dissolved organic matter (DOM) derived from various plants that dominate the Florida Everglades. Plant-derived DOM leachate samples were exposed to photochemical and microbial degradation and the optical, chemical, and molecular weight characteristics measured over time. Optical parameters such...
We have previously reported that intrauterine (i/u) administration of epidermal growth factor (EGF 500 ng) on day (d) 21 of pregnancy delayed 19.0 +/- 0.6 h the onset of labor. Progesterone (P) is secreted by ovarian corpora lutea (CL) throughout gestation in the rat. Prepartum CL regression due to increased uterine cyclooxygenase I and prostaglandin F(2alpha) results in P withdrawal followed b...
Trisomy 21 (T21), Down Syndrome (DS) is the most common genetic cause of dementia and intellectual disability. Modeling DS is beginning to yield pharmaceutical therapeutic interventions for amelioration of intellectual disability, which are currently being tested in clinical trials. DS is also a unique genetic system for investigation of pathological and protective mechanisms for accelerated ag...
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