Historically, the design of the in-stope pillar in underground excavations has been based on empirical formulae and numerical modelling. Although these design methods have been extensively applied in several gold mines in South Africa, rockburst, in-stope pillar burst/failure are continuously reported as the major problem faced by mines. Therefore, this study attempts to compare the performance...

analysis and prediction of structural response to static or dynamic loading requires prediction of concrete response tovariable load histories. the constitutive equations for the mechanical behavior of concrete capable of seeing damage effects or crack growth procedure under loading/unloading/reloading was developed upon micro-plane framework. the proposed damage formulation has been built on t...

The U.S. National Toxicology Program has shown clear evidence of carcinogenicity of nickel subsulfide (Ni(3)S(2)) and some evidence of carcinogenicity of NiO (green) in rats. In the present study, DNA damage in cultured cells and in lungs of rats induced by nickel compounds was investigated to clarify the mechanism of nickel carcinogenesis. In cultured HeLa cells, Ni(3)S(2) induced a significan...

this study aimed to investigate effects of malathion on dna breakage in the liver and gill of rainbow trout (oncorhynchus mykiss) in the laboratory condition. the experiment was performed with four concentrations of malathion, i.e. 0 (control), 0.025, 0.05 and 0.075 mg l‑1 and three replicate for nine days. the liver and gill were sampled on the first, fifth and ninth days after the start of th...

Objective(s): Despite several proposed mechanisms for the pathophysiology of cardiorenal syndrome (CRS), the exact mechanism remains unclear. Nitrosative stress has been argued as a key mechanism recently. Nebivolol is a beta-blocker with nitric oxide (NO)-releasing effect. In the present study, NO-mediated effects of two different treatment regimes of nebivolol in CRS...

kinematic synthesis of a trailing six-member mechanism has been carried out to achieve five precision points of an automotive steering mechanism. the inner wheel can be rotated up to forty five degrees with fair accuracy. results show that the divergent end behavior of ackermann steering mechanism has been overcome by the present mechanism. the work is similar to earlier work by the present aut...

Background: Recent results have provided increasing evidence to support involvement of membrane damage in the mechanism of ionizing radiation induced killing of mammalian cells. These findings have stimulated renewed interest in evaluating the damage to membrane as a primary initiator in radiation-induced cell killing especially in apoptotic death. The present study was aimed to gain deeper ins...