Brain derived neurotrophic factor (BDNF) is a member of neurotrophic family of growth factors, mainly found in the hippocampus and cerebral cortex of brain. Studies have shown that there is a link between BDNF and cognitive dysfunction, as well as there is a relationship between the PUFAs intake and their effect on BDNF production. Intake of PUFAs, mainly omega-3 and omega-6 has show increase i...

EFFECT OF LOW ENDOGENOUS BRAIN-DERIVED NEUROTROPHIC FACTORLEVELS ON STRIATAL DOPAMINE DYNAMICSbyFRANCIS KABUI MAINADecember 2011Advisor: Dr. Tiffany A. MathewsMajor: Chemistry (Analytical)Degree: Doctor of PhilosophyMany neurological diseases and disorders are a result of alterations withneurotransmitters, neuromodulators, and/or proteins. Specifically, one p...

Brain-derived neurotrophic factor (BDNF) is a neurotrophin which promotes a variety of neural processes ranging from neuronal health to the survival in the peripheral and central nervous systems. There is interest in serum BDNF as a potential biomarker of anxiety disorders in pet dogs for veterinary and comparative behavior research. As an initial step in applying BDNF in canine research, work ...

PURPOSE Glaucoma, frequently associated with elevated intraocular pressure (IOP), is characterized by progressive retinal ganglion cell (RGC) death and vision loss. Brain-derived neurotrophic factor (BDNF) has been studied as a candidate for neuroprotection in rodent models of experimental glaucoma, yet it remains to be determined whether BDNF exerts long-term protection for subtype RGCs and vi...

Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are molecules which regulate the development and maintenance of specific functions in different populations of peripheral and central neurons, amongst them sensory neurons of neural crest and placode origin. Under physiological conditions NGF is synthesized by peripheral target tissues, whereas BDNF synthesis is highest in t...

Introduction: There are several hypotheses of schizophrenia pathogenesis, including the neurodegenerative theory, which is supported by evidence for decrease neuroprotective factors’ serum levels. The proteins, that exert a protective effect on neurons and researched concerning include brain-derived neurotrophic factor (BDNF), nerve growth (NGF), neurotrophin 3 (NT3), glial cell line-derived (G...

Neonatal sciatic nerve injury is known to result in an extensive loss of lumbar motor neurons as well as the disappearance of their respective muscle fibers in the hindlimb musculature. The loss of motor neurons and muscle fibers can be prevented by immediate administration of target-derived neurotrophic factors to the site of injury. In the present study, we investigated the role of ciliary ne...