background a few studies are available actually comparing the clinical efficacy of intravenous acetaminophen with other medications such as dexamethasone to inhibit postoperative adverse events in children. objectives this randomized blinded controlled trial was designed to compare controlling status of postoperative events in children after tonsillectomy randomized to receive either intravenou...

INTRODUCTION Traumatic joint injury damages cartilage and causes adjacent joint tissues to release inflammatory cytokines, increasing the risk of developing osteoarthritis. The main objective of this study was to determine whether the combined catabolic effects of mechanical injury, tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6)/soluble IL-6 receptor (sIL-6R) on cartilage could be ...

BACKGROUND Glucocorticoids are commonly administered before ambulatory surgery, although their effects on quality of recovery are not well characterized. The purpose of this study was to evaluate the dose-dependent effects of dexamethasone on patient recovery using the Quality of Recovery 40 questionnaire (QoR-40) after ambulatory surgery. METHODS This prospective, double-blind trial studied ...

traumatic brain injury (tbi) initiates a cascade of numerous pathophysiological events that evolve over time. despite the complexity of tbi, research aimed at therapy development has almost exclusively focused on single therapies, all of which have failed in multicenter clinical trials. a variety of brain insults, including traumatic brain injury, encephalitis, stroke, and status epilepticus (s...

background postoperative pain is considered as a reason of patient’s delay in discharge and disability aggravation. therefore, multimodal approaches have been suggested in order to mitigate pain and decrease postoperative side effects. objectives the aim of this study was to evaluate analgesic effect of a single dose injection of dexamethasone on reducing postoperative pain in laparoscopic chol...

biodegradable nanoparticulate carriers, have important potential applications for administration of therapeutic molecules. chitosan based nanoparticles have attracted a lot of attention upon their biological properties such as biodegradability, biocom-patibility and bioadhesivity. the aim of the present investigation was to describe the synthesis and characterization of novel biodegradable nano...

BACKGROUND AMS is a disease that occurs when accessing high altitude (HA) or upon exposure to a higher altitude after acclimatising over 3,000 m. Evidence shows that drugs can prevent AMS. The function of dexamethasone for preventing AMS is important. No systematic review has previously been published about the effect of dexamethasone. The effect of intervention is unclear, which has limited th...

OBJECTIVES To investigate the effect of dexamethasone on triggering receptor expressed on myeloid cells-1 (TREM-1). METHODS Wild-type and tumor necrosis factor (TNF (-/-)) mice were pre-treated with saline, dexamethasone, or hydrocortisone and exposed to a lethal infection of Pseudomonas aeruginosa. Mortality and TREM-1 on neutrophil membranes was measured after sacrifice. U937 human monocyti...

In this double blind, randomized placebo-controlled study, the effect of dexamethasone in two different doses 0.5mg/kg and 1mg/kg on prevention of postoperative vomiting in children undergoing tonsillectomy with or with out adenoidectomy by electrodissection was evaluated. One hundred fifty children were involved in this study; children were allocated randomly into three equal groups. Children ...