نتایج جستجو برای: digitoxin

تعداد نتایج: 354  

Journal: :Clinical Chemistry and Laboratory Medicine 1986

Journal: :Circulation 1951
M J GREVE E E EDDELMAN W S EISENBERG T R HARRISON

2013
Frank E. McDonald

The research enterprise in our laboratory is based on the premise that many conceptually simple chemical transformations can be envisioned which have not yet been reduced to practice. This account presents the discovery and current state of optimization of a new reaction which was recently discovered in our laboratories, namely the tungsten carbonyl-catalyzed endo-selective cycloisomerization o...

Journal: :Folia Pharmacologica Japonica 1955

Journal: :Bioorganic & medicinal chemistry letters 2008
Joseph M Langenhan Jeffery M Engle Lauren K Slevin Lindsay R Fay Ryan W Lucker Kyle R Smith Matthew M Endo

A chemoselective reaction between oxyamines and unprotected, unactivated reducing sugars was used to construct for the first time a panel of linkage-diversified neoglycosides. This panel of digitoxin analogs included potent and selective tumor cytotoxins; cytotoxicity was dependent on the structure of the glycosidic linkage. These results validate linkage diversification through neoglycosylatio...

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