نتایج جستجو برای: disease gene prediction
تعداد نتایج: 2663465 فیلتر نتایج به سال:
Despite the considerable progress in disease gene discovery, we are far from uncovering the underlying cellular mechanisms of diseases since complex traits, even many Mendelian diseases, cannot be explained by simple genotype-phenotype relationships. More recently, an increasingly accepted view is that human diseases result from perturbations of cellular systems, especially molecular networks. ...
Abstract: In disease gene identification and classification, users are only interested in classifying one specific class, disease genes, without considering other classes (non-disease genes). This situation is referred to as one-class classification. Existing machine learning-based methods typically use known disease gene as positive training set and unknown genes as negative training set to bu...
Classification tree models have ability to discover and evaluate interactions of multiple predictor variables, and define flexible, nonlinear predictive tools. We have developed tree models for clinical prediction studies with very high-dimensional gene expression data as candidate predictors. A first context is Bayesian tree models for predicting binary outcomes (as an example), that respects ...
Abstract Background: Adult T-cell leukemia/lymphoma (ATLL) is caused by human T-cell lymphotropic virus type-1 (HTLV-1). HTLV-1 oncogenes can induce malignancy through controlled gene expression of cell cycle checkpoints in the host cell. HTLV-I genes play a pivotal role in overriding cell cycle checkpoints and deregulate cellular division. In this study, we aimed to determine and comp...
While a growing body of evidence implicates regulatory miRNA modules in various aspects of human disease and development, insights into specific miRNA function remain limited. Here, we present an innovative approach to elucidate tissue-specific miRNA functions that goes beyond miRNA target prediction and expression correlation. This approach is based on a multi-level integration of correspondin...
نظر به اهمیت و تاثیر روزافزون عوامل روانی – اجتماعی در سلامت جسمی و تاثیر عوامل روان شناختی در بروز بیماریهای مختلف از جمله بیماریهای قلبی و عروقی این پژوهش با هدف کلی بررسی ارتباط تیپ شخصیتی d ، حمایت اجتماعی و خود دلسوزی در پیش بینی رفتارهای بهداشتی بیماران کرونر قلبی و تعیین تفاوت بین بیماران کرونر قلبی با و بدون جراحی و افراد سالم در این متغیرها و رفتارهای بهداشتی آنان، انجام گرفت. جامعه آ...
Accumulated biological knowledge is often encoded as gene sets, collections of genes associated with similar biological functions or pathways. The use of gene sets in the analyses of high-throughput gene expression data has been intensively studied and applied in clinical research. However, the main interest remains in finding modules of biological knowledge, or corresponding gene sets, signifi...
late blight, caused by phytophthora infestans, is one of the most important diseases of potato in the world and iran, especially in golestan province. 16 models have introduced for forecasting the disease in the world, sofar. in order to developing a forecasting model, wether and disease occurrence data during the recent 10 years were used.then, 22 variables were built using daily temperature, ...
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