Post-traumatic osteoarthritis (PTOA) develops following traumatic articular insult.1 One model system used to study the progression and treatment of PTOA is destabilization medial meniscus (DMM) as first described by Glasson et al performed in mini-pigs.2–7Miniature-pigs are less available, more expensive have synovial fluid sampling limitations, limiting availability OA biomarkers compared dom...

Excessive Activity of Cathepsin K is Associated with the Cartilage Defects in a Zebrafish Model for Mucolipidosis II Aaron C. Petrey*, Heather Flanagan-Steet*, Steven Johnson, Xiang Fan, Mitche De la Rosa, Mark E. Haskins, Alison V. Nairn, Kelley W. Moremen, Richard Steet 1 Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA 2 Departments of Pathobiology and Clini...

Problem statement for distributed and dynamic mobility management draft-chan-distributed-mobility-ps-03 Abstract The traditional hierarchical structure of cellular networks has led to deployment models which are heavily centralized. Mobility management with centralized mobility anchoring in existing hierarchical mobile networks is quite prone to suboptimal routing and issues related to scalabil...

Refining a topology of a distributed messaging middleware (DMM) is an important management technique to provide a better service to the end-users. Nevertheless, determining the appropriate steps to transform a DMM from one topology to another, in a way that minimizes service disruptions, has received little attention. This is a critical problem since service disruptions can be particularly harm...

We present three shared memory simulations on distributed memory machines (DMMs), which use universal hashing to distribute the shared memory cells over the memory modules of the DMM. We measure their quality in terms of delay, time-processor eeciency, memory contention (how many requests have to be satissed by one memory module per simulated step) and simplicity. Further we take into considera...

Assume that a set U of memory locations is distributed among n memory modules, using some number a of hash functions h1; : : : ; ha, randomly and independently drawn from a high performance universal class of hash functions. Thus each memory location has a copies. Consider the task of accessing b out of the a copies for each of given keys x1; : : : ; xn 2 U , b < a. The paper presents and analy...

An alpha 1,2-mannosidase (Man9-mannosidase) involved in N-linked oligosaccharide processing has been purified about 16,000-fold from pig liver crude microsomes (microsomal fractions) by CM-Sepharose and DEAE-Sephacel chromatography, concanavalin A (Con A)-Sepharose chromatography and, as the key step of the procedure, affinity chromatography on immobilized N-5-carboxypentyl-l-deoxymannojirimyci...

Yougui pills (YGPs) have been used for centuries in the treatment of Chinese patients with Kidney-Yang Deficiency Syndrome. Despite the fact that the efficiency of YGPs on treating osteoarthritis has been verified in clinic, the underlying mechanisms are not totally understood. The present study observes the therapeutic role of YGPs and mechanisms underlying its chondroprotective action in oste...

Due to the growing interest in dimethoxymethane (DMM) as formaldehyde synthon and fuel additive, new more efficient routes toward analog are being investigated. One approach is reductive transformation of carbon dioxide using a ruthenium phosphine catalyst Lewis acid additive methanol. In present work, we investigated underlying reaction network, consisting several intermediates, equilibria sid...