The aim of this review is to give an overview of the extracellular matrix (ECM) components that are important for creating structural changes in the premetastatic and metastatic niche. The successful arrival and survival of cancer cells that have left the primary tumor and colonized distant sites depends on the new microenvironment they encounter. The primary tumor itself releases factors into ...

Recent advances in mobile computing enable many new applications, yet at the same time create privacy implications caused by the increasing amount of data that becomes available. This thesis will explore the possibilities of wireless-enabled portable devices and their attending privacy implications. We will describe how such a device containing personal information about the musical preferences...

KEY CLINICAL MESSAGE The cost of treating metastatic colorectal cancer has increased significantly after the introduction of targeted antivascular therapies. We report the unusual case of a patient with colorectal cancer with several large liver metastases at diagnosis, who was cured after removal of the primary tumor and treatment with 5-FU/LV only.

after having practicing and researching health economics for nearly 15 years now, it has become clear to me that the use of cost-effectiveness data in priority setting decisions is rather a rare than a common practice. the eckard et al.article though, describes a wonderful exception to this rule and a very good example of how it can be used when the conditions are right. however, do we fully un...

background and purpose: special attention has been paid to instructor and preceptor in nursing and midwifery education. this study aims to explore the experiences and perceptions of midwifery students about implementing preceptorship program in delivery setting. methods: the current study is a qualitative research. the focus groups and in-depth interviews were used as data collection tools. tar...

trend- setting for the field of persian language and literature is the subject of the present paper. the author believes in setting of such a trend, and criticizes the reasons of opposing ones, citing his own proofs. he also enumerates his considerations about trend-setting circumstances at the end. trend- setting for the field of persian language and literature is the subject of the present pa...

Background Priority setting in healthcare is a key determinant of health system performance. However, there is no widely accepted priority setting evaluation framework. We reviewed literature with the aim of developing and proposing a framework for the evaluation of macro and meso level healthcare priority setting practices.   Methods We systematically searched Econlit, PubMed, CINAHL, and EBSC...