Background: Hyaluronan (HA) is a structural component of extracellular matrix synthesised by HA synthases HAS1-3, which produce HA of different molecular sizes with distinct biological functions associated with reproductive processes. Hyaluronidase (HYAL) cleaves the HA into biologically active small fragments which are known to regulate cell proliferation through CD44 receptor signaling. HA is...

Busulfan is an alkylating agent affects ovarian follicles growth by oxidative stress induction. Satureja khuzestanica has antioxidant effects. The aim of this study was to examine whether S. khuzestanica essential oil (SKEO) exhibits protective effects on busulfan-induced ovarian failure. Eighty-four adult female mice were divided into six groups including dimethyl sulfoxide (...

The fact that embryos can be obtained in vitro undermines the role of the oviduct. However, it has been demonstrated that when in vitro produced bovine zygotes are cultured in the oviduct of sheep, cattle or mice the embryo quality is improved compared to the embryos produced in vitro. Thus the oviduct is not simply a passive organ required only for transporting the embryo to the uterus but als...

the main factors affecting pregnancy and implantation rates are uterine receptivity, embryo quality, and transfer efficiency. embryo transfer (et) is the last step of critically important procedure of in vitro fertilization (ivf) and probably the least successful step in assisted reproductive technology (art) treatment cascade; though simple in most of the cases, it may pose to be the most diff...

background: sperm dna fragmentation is known as an important cause of male infertility. the influence of sperm dna damage on reproductive potential has been subject of many studies indicating various results and remaining the subject controversial. in this study, we investigated differences of the semen parameters and intracytoplasmic sperm injection (icsi) outcome according to sperm dna fragme...

CONTEXT Our center's quality improvement optimization process on many occasions anecdotally suggested that oocyte assessments might enhance embryo assessment in predicting pregnancy chances with in vitro fertilization (IVF). OBJECTIVE To prospectively compare a morphologic oocyte grading system to standard day-3 morphologic embryo assessment. DESIGN, SETTING, PATIENTS We prospectively inves...

Embryo quality and embryo selection are critical criteria for embryo transfer and subsequently success of assisted reproductive technologies (ART). Transfer of good quality embryos is associated with increased implantation, pregnancy and live birth rates and also decreased pregnancy loss and prenatal complications in comparison with transfer of embryos with impaired quality. Furthermore, advanc...

Background: To examine the relative contributions of dietary fat intake level and its food sources and assisted reproduction parameters. Materials and Methods: A prospective study was conducted on 240 infertile women. In assisted reproduction treatment cycle, body mass index (BMI), physical activity (PA), calorie intake, fat consumption and major food sources were assessed. The number of retrie...

BACKGROUND The aetiology of recurrent miscarriage (RM) remains largely unexplained. Women with RM have a shorter time to pregnancy interval than normally fertile women, which may be due to more frequent implantation of non-viable embryos. We hypothesized that human endometrial stromal cells (H-EnSCs) of women with RM discriminate less effectively between high-and low-quality human embryos and m...