In most multicellular organisms, homeostasis is contingent upon maintaining epithelial integrity. When unanticipated insults breach epithelial barriers, dormant programmes of tissue repair are immediately activated. However, many of the mechanisms that repair damaged epithelia remain poorly characterized. Here we describe a role for Plexin A (PlexA), a protein with particularly well-characteriz...

objective(s) wound healing represents a dynamic physiological process influenced by many factors. the aim of the present study was to evaluate the effects of teucrium polium honey on the wound healing and tensile strength in rat. materials and methods thirty-six sprague-dawley rats were randomly divided into four equal (n= 9) treatment and control groups. two full-thickness wounds were made ove...

Current knowledge about Periostin biology has expanded from its recognized functions in embryogenesis and bone metabolism to its roles in tissue repair and remodeling and its clinical implications in cancer. Emerging evidence suggests that Periostin plays a critical role in the mechanism of wound healing; however, the paracrine effect of Periostin in epithelial cell biology is still poorly unde...

OBJECTIVE In recent years, there has been a tendency to search for regulatory substances that can optimize the healing process of perforated tympanic membranes (TMs). The purpose of this study was to determine the effects of using topical insulin on the healing process of traumatic TMs perforations. STUDY DESIGN Experimental. METHODS Tympanic membranes of 20 Wistar rats were perforated in t...

PURPOSE To determine the distribution of type XVIII collagen in mouse ocular tissues and to investigate the expression of type XVIII collagen during healing of corneal incisions and keratectomy wounds. METHODS Immunohistochemical analysis of type XVIII collagen was performed in mouse ocular tissue, with polyclonal antibodies to the hinge domain. For wound-healing experiments, excimer laser ke...

Mixed-lineage kinase 3 (MLK3) activates multiple MAPK pathways and can initiate apoptosis, proliferation, migration, or differentiation in different cell types. However, whether MLK3 signaling regulates intestinal epithelial cell sheet migration in vivo is not known. We sought to investigate whether MLK3 signaling is important in intestinal mucosal healing and epithelial cell motility in vivo a...

introduction: the aim of this work was to evaluate the effects of four different concentrations of aloe vera extract on healing of second degree burns in male wistar rats. materials and methods: by an experimental study 42 male wistar rats were divided into 7 equal groups. the burn injury was made on the back of all rats, according to standard methods. the burned areas in the group1: were left ...

UNLABELLED The most common etiologies of tympanic membrane perforation are infections and trauma. OBJECTIVE The objective of the present study was to assess the healing of traumatic tympanic membrane perforation in rats. METHODS The tympanic membrane from male Wistar rats was perforated in the anterior and posterior portions to the handle of the malleus. Five tympanic membranes were evaluat...

Mucosal damage is a key feature of inflammatory bowel diseases (IBD) and healing the mucosa an endpoint IBD treatment that often difficult to achieve. Autonomic neurons parasympathetic sympathetic nervous system may influence intestinal epithelial cell growth modulating innervation could for reason serve as interesting therapeutic option improve mucosal healing. Understanding biological process...