purpose : to evaluate the effect of topical diclofenac sodium 0.1% on the corneal epithelial healing after photorefractive keratectomy (prk) methods : in this prospective randomized double blind clinical trial, prk was performed on 82 patients. thirty-three cases of them receiving topical diclofenac four times per day after surgical procedure and 45 patients did not receive this medication as a...

determinants of early onset haze were retrospectively explored in patients who had been undergone laser-assisted sub-epithelial keratectomy (lasek) in a private eye clinic. the technique included creating an epithelial flap following 20 seconds exposure to 20% alcohol. ‘optimized’ ablation profile was used by allegretto laser (wavelight technologie). following repositioning of the flap, a singl...

purpose: to evaluate the effect of topical phenytoin 1 % on corneal epithelial defects healing in a rabbit model. methods: one eye of 20 albino rabbits in the animal house of al-zahra ophthalmology hospital was studied. a single corneal epithelial defect was created. the rabbits were randomly assigned into two groups (ten animals in each group). after creating a chemical burn in rabbits, one gr...

The kinetics of rabbit corneal epithelium regeneration were studied to determine if topical corticosteroid has an adverse effect on corneal epithelial wound healing, and if epidermal growth factor (EGF) can abrogate any adverse effect of topical corticosteroid. Healing of standardized 7 mm. central corneal epithelial wounds was determined by serial standardized color photography of the flouresc...

purpose : studies show that phenytoin is effective in improvement of different chronic ulcers such as venous stasis ulcers, and diabetic ulcers. the exact mechanism is yet not clear investigators thought that phenytoin might help to heal intractable corneal ulcers by reducing inflammation, differentiating limbal fibroblasts, and promoting the invasion of the cornea with new blood vessels as sho...

PURPOSE Vascular endothelial growth factor (VEGF) is essential for neovascularization, but the use of anti-VEGF therapies to inhibit neovascularization may influence epithelial wound healing. Here, the effects of bevacizumab on corneal epithelial wound healing time in rabbit models, cell proliferation, and expression of integrins in human corneal epithelial and fibroblast cells were evaluated. ...

A patient with severe non-healing microscopically proven Nocardia keratitis was treated with maximal topical amikacin followed by amniotic membrane transplantation (AMT) 2 months later (single-layer epithelial side-down). Epithelial healing was achieved, but neovascularization continued. This case report indicates that AMT combined with topical antibiotic provides pain relief and allows epithel...

PURPOSE To establish a rat model of neurotrophic keratopathy and to examine the effects of the combination of substance P (SP) and insulin-like growth factor (IGF)-1 on corneal epithelial barrier function and wound healing in this model. METHODS Corneal denervation was achieved by thermocoagulation of the ophthalmic branch of the trigeminal nerve. A modified Schirmer test was performed withou...

PURPOSE Ocular surface and corneal epithelial wounds are common and potentially debilitating problems. Ideal treatments for these injuries would promote epithelial healing without inflammation, infection and scarring. In addition the best treatments would be cost-efficient, effective, non-toxic and easily applied. Histatin-1 peptides have been shown to be safe and effective enhancers of epithel...