Floating matrix tablets of cefixime trihydrate were developed to prolong gastric residence time and to increase drug absorption and hence bioavailability. Hydrophilic polymers viz. HPMC K4M and Xanthan gum were incorporated in varied proportions to develop floating matrix tablets of cefixime by direct compression method. Buoyancy was achieved by adding an effervescent mixture of sodium bicarbon...

Famotidine has been the most widely used drug for the treatment of peptic ulcer for many decades. The present investigation concerns the development and evaluation of floating tablets of famotidine which, after oral administration, are designed to prolong the gastric residence time, increase drug bioavailability and target the gastric ulcer. A floating drug delivery system (FDDS) was developed ...

Floating drug delivery systems (FDDS) are utilized to target discharge in the stomach or upper parts of intestine. Famotidine has been most extensively used for management peptic ulcer various decades. The current study concerns development and evaluation floating tablets famotidine which, after oral administration, planned extend gastric residence time, enhance bioavailability aim ulcer. A FDD...

This paper presents H∞ control problem for input-delayed systems. A neutral system approach is considered to the design of PD controller for input delay systems in presence of uncertain time-invariant delay. Using this approach, the resulting closed-loop system turns into a specific time-delay system of neutral type. The significant specification of this neutral system is that its delayed coeff...

Nifedipin merupakan salah satu obat yang sering digunakan dalam pengobatan hipertensi dengan frekuensi penggunaan berulang kali sehari, karena itu nifedipin perlu diformulasikan bentuk sediaan lepas lambat. Banyak metode dapat untuk membuat lambat, satunya adalah dirancang tetap tinggal di lambung. Penelitian ini bertujuan mengetahui pengaruh konsentrasi natrium bikarbonat sebagai komponen effe...

the main objective of the present study was to formulate gastroretentive effervescent sustained release drug delivery systems of risperidone floating tablets with the help of methocel® k15, ethocel® standard 7fp premium, eudragit ® rs100 sustained release polymers to improve its safety profile, bioavailability and patient compliance. risperidone floating tablets were formulated by wet granulati...

This paper deals with the robust output tracking problem of uncertain large-scale systems with input delay and the time-delay interconnections. Due to the informat ion transmission between subsystems, time delays are often encountered in large-scale systems and lead to the source of system instability. First, the original nonlinear time-delay systems can be represented by the Takagi-Sugeno fuzz...

OBJECTIVE DA-9601, an extract of Artemisia asiatica containing eupatilin and jaceosidin as active compounds, has been prescribed to treat gastritis in Asia. In recent times, sustained-release, floating gastroretentive (GR) tablets of DA-9601 are available on the market. In the present study, the physical properties and in vitro drug release profile, in vivo gastric residence time, and gastropro...