Self-assembling minimalistic peptides embedded with an organocatalytic moiety were designed. By controlling the formation of fibrils via external intervention, it was shown that activation is accelerated when organocatalyst in its supramolecular state. The effect catalysis demonstrated a Michael benchmark reaction.

The commercial availability of random peptide libraries displayed on the M13 phage is increasing their use forstudies on epitope identification, enzyme inhibitors, receptor ligands, etc. In this study two experimentswhere planned for selection of peptides. First with sheep antibodies, the positive selector was IgG, preparedon Protein G column from a pool of 11 sheeps immunized...

Abstract Plant genomes encode hundreds of receptor kinases and peptides, but the number known plant receptor-ligand pairs is limited. We report that Arabidopsis leucine-rich repeat kinase LRR-RK MALE DISCOVERER 1-INTERACTING RECEPTOR LIKE KINASE 2 (MIK2) for SERINE RICH ENDOGENOUS PEPTIDE (SCOOP) phytocytokines. MIK2 necessary sufficient immune responses triggered by multiple SCOOP suggesting t...

background: leishmaniasis is a worldwide disease prevalent in tropical and sub- tropical countries. in the present study the immunogenicity of three human hla-dr1 restricted peptides derived from l. major gp63 protein was evaluated using fvb/n-dr1 transgenic mouse model. methods: the immunity generated by three mhc class ii – restricted peptides with the sequence of aarlvrlaaagaavt (aar), aaplv...

Recent evidence identified multiple Henipavirus species in Africa distinct from those in Southeast Asia and Australia. The reported fusion glycoprotein (F) sequence of the African Gh-M74a strain (GhV-F) is likely incorrect: a single base pair deletion near the N terminus results in multiple aberrancies. Rectifying this by adding single nucleotide insertions results in a GhV-F that now possesses...

The glycation of BSA leads to protein/peptide modifications that result in the formation of AGEs. AGEs react with the amino groups of N-terminal amino acid residues, particularly arginine and lysine residues. Enhanced AGE formation exists in the blood and tissues of diabetics, as well as in aging and other disorders. The Identification of AGEs is of great importance. Mass spectrometry has been ...