The interest in cannabis-based products for the treatment of refractory epilepsy has skyrocketed in recent years. Marijuana and other cannabis products with high content in Δ(9) - tetrahydrocannabinol (THC), utilized primarily for recreational purposes, are generally unsuitable for this indication, primarily because THC is associated with many undesired effects. Compared with THC, cannabidiol (...

Neurocognitive impairment is frequent in epilepsy patients. Causes are multiple, and may be influenced by several factors including the epilepsy syndrome. Most cognitive complaints in adult patients are mental slowness, memory difficulties and attention deficits. In children, cognitive problems are more diffuse, responsible for language troubles, learning difficulties, poor academic outcome, be...

The indications for surgical intervention epilepsy associated with chromosomal abnormalities remain controversial. We report a 13-year-old girl trisomy 21 and refractory epilepsy. patient developed West syndrome at the age of 5 months. seizures were to multiple antiepileptic drugs, adrenocorticotropic hormone therapy, ketogenic diet. Lennox-Gastaut 7 years. Frequent daily including several soun...

Lennox-Gastaut syndrome (LGS) has a major impact on the health-related quality of life (HRQL) of the affected children as well as their caregivers. The primary caregiver in the family is generally the mother, with support from the father and siblings. The burden of care and the effects of the disease on the child necessitate adjustments in virtually all aspects of the lives of their family. The...

ObjectiveLennox-Gastaut syndrome (LGS) is a severe drug-resistant epilepsy (DRE) of childhood. The Vagus Nerve Stimulator (VNS) established as safe and effective treatment for DRE. This study assesses efficacy tolerability the auto-stimulation VNS models in pediatric patients with LGS.MethodsThis retrospective chart review cohort (Age 1–18 years old) LGS implanted an model at single level four ...

A 47-year-old man presented with tonic-clonic seizures characterized by convulsions. He repeatedly exhibited despite treatment four anti-seizure medications. During the titration process of perampanel (PER), paradoxically increased in intensity and frequency, resulting trauma. Video electroencephalogram monitoring revealed interictal rapid rhythms generalized spikes documented atonic seizures. ...