objective the lennox-gastaut syndrome (lgs), one of the most difficult epilepsy syndromes to treat, is characterized by a triad of intractable seizures of various types, a slow (< 2.5-hertz) spike-wave pattern in eeg and mental retardation. the aim of this study was to evaluate the efficacy and safety of lamotrigine as add-on therapy in intractable epilepsy of children with lgs. materials & met...

OBJECTIVE This review summarizes the treatment of Lennox-Gastaut syndrome, an intractable epileptic encephalopathy of early childhood. In particular, the review focuses on rufinamide, a recently released anticonvulsant medication with reported effectiveness in this epilepsy syndrome. METHODS A systematic literature search (PubMed) was performed to review the existing literature pertaining to ...

We investigated humoral and cellular immune response to brain tissues in 15 patients with West syndrome, in 9 patients with Lennox-Gastaut syndrome and in 20 healthy children. High levels of a precipitating antibody to a saline extract of brain tissue were detected in all patients; leucocyte migration inhibition test with the same antigen was found to be positive in most of them. The role of th...

The clinical symptoms associated with chromosome 15q duplication syndrome manifest through a heterogeneous group of symptoms characterised by hypotonia, delay in motor skills and language development, cognitive and learning disabilities, autism spectrum disorder and refractory epilepsy. The late development of Lennox-Gastaut syndrome in patients with 15q11q13 duplication is a possibility that p...

21 new cases of infantile spasms were reported in 1976 from paediatric departments in Denmark. The connection between infantile spasms and the Lennox-Gastaut syndrome is mentioned, because of reports of a significantly higher incidence of HLA-B7 in children with Lennox-Gastaut syndrome. The HLA antigen distribution in 19 of the 21 children was compared with that of 1967 healthy adults. No diffe...

background: lennox-gastaut syndrome (lgs) is an epileptic encephalopathy, characterized by drug-resistant multiple seizure types. the aim of this study was to determine if the adjunctive use of electroconvulsive therapy (ect) in patients with lgs and drug-resistant epilepsy is efficacious in decreasing their seizure frequency and also to investigate its safety and tolerability.   methods: this ...

Background: Cannabidiol (CBD) is a non-psychoactive substance of Cannabis sativa effective in refractory epilepsy due to Dravet syndrome, Lennox-Gastaut syndrome and Tuberous Sclerosis Complex, with few studies other etiologies. There are that show benefit the mutual use clobazam CBD.

PURPOSE Bilateral frontoparietal polymicrogyria (BFPP) has been reported in sporadic patients and in recessive pedigrees. Eleven mutations in GPR56, a gene encoding an evolutionarily dynamic G-protein-coupled receptor, have been identified in 29 patients from 18 families. The clinical features of BFPP include severe mental retardation, motor and language impairment, and epilepsy. No detailed de...

بيصت ةديدش ةيعرص ةمزلاتم يه وتساج سكونيل ةمزلاتم ةرركتمو ةعونتم ةيبصع تاجنشت ةباصإب زيمتتو لافطلأا ةئيطب ةيئابرهك تانحشو روهدتم ينهذ رخأتب ةبوحصم نادقفب ةبوحصلما ةيبصعلا تاجنشتلا لثتمو .غامدلا طيطختب ةيعون روهدتو ةيدسلجا تاباصلإاب ةروطخ طوقسلاو ةكرلحا ةلوهسب بيجتست لا تاجنشتلا هذه نأ ملعلا عم .ةيمويلا ةايلحا .ضرغلا اذهل ديامانيفورلا راقع ريوطت تم اًيلاحو يئاودلا جلاعلل ضعب مادختسا نكميف يئاودلا ...