Stem Cells & Cancer Group, CNIO, Madrid, Spain Viral Vector Unit, Spanish National Cardiovascular Research Centre (CNIC), Madrid, Spain Gastrointestinal Cancer Clinical Research Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain Department of Molecular Gastrointestinal Oncology, Ruhr-University Bochum, D-44801 Bochum, Germany Barts Cancer Institute, Centre for Stem Cells in Can...

Long non-coding RNAs (lncRNAs) are recently discovered RNA transcripts that are aberrantly expressed in many tumor types. Numerous studies have suggested that lncRNAs can be utilized for cancer diagnosis and prognosis. LSINCT5 (long stress-induced non-coding transcript 5) is dramatically upregulated in breast and ovarian cancer and affects cellular proliferation. However, the expression pattern...

As a DNA repair protein, Flap endonuclease 1 (FEN1) plays crucial parts in preventing carcinogenesis. Two functional germ line variants (-69G > A and 4150G > T) in the FEN1 gene have been associated with DNA damage levels in coke oven workers and lung cancer risk in general populations. However, the role of these genetic variants on gastrointestinal cancer susceptibility is unknown. Therefore, ...

cancer and the intestinal type of gastric cancer usually follows stepwise progression with recognizable pre-neoplastic changes (i.e., adenoma and intestinal metaplasia for colorectal and gastric cancers, respectively). Therefore, screening and early diagnosis remain the preferred options to ease the disease burden. Surgical resection is the mainstay treatment for gastrointestinal cancers. Other...

Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Department of Biostatistics and Epidemiology, Yokohama City University Medical Center, Yokohama, Japan, Department of Surgery, Kitasato University, Sagamihara, Department of Surgery, Yokohama City University Medical Center, Yokohama, Department of Gastroenterological and General Surgery, Saint Marianna University, Kawasaki, Departm...

Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors of the gastrointestinal tract with immunohistochemical reactivity for CD117 antibody. Gastrointestinal stromal tumor with synchronous gastric cancer is rare. A 69-year-old male presented with one-week history of epigastrium pain and vomit was admitted to our hospital. Subtotal gastrectomy and D2 lymph node dissection were performed,...

Objective: Direct oral anticoagulants (DOAC) are now considered an effective treatment option for cancer associated thrombosis (CAT). There still controversies in the use of DOACs CAT with gastrointestinal (GI) malignancies.

Studies in humans have shown that 3,3'-diindolylmethane (DIM), which is found in cruciferous vegetables, such as cabbage and broccoli, is effective in the attenuation of gastrointestinal cancers. This review presents the latest findings on the use, targets, and modes of action of DIM for the treatment of human gastrointestinal cancers. DIM acts upon several cellular and molecular processes in g...