Nonmotor symptoms (NMS) like neuropsychiatric symptoms, sleep disturbances or autonomic symptoms are a common feature of Parkinson's disease (PD). To explore the existence of groups of NMS and to relate them to PD characteristics, 71 idiopathic non-demented PD out-patients were recruited. Sleep was evaluated by the PD Sleep Scale (PDSS). Several neuropsychiatric, gastrointestinal and urogenital...

BACKGROUND Evidence suggests that many coeliac disease patients suffer from persistent clinical symptoms and reduced health-related quality of life despite a strict gluten-free diet. We aimed to find predictors for these continuous health concerns in long-term treated adult coeliac patients. METHODS In a nationwide study, 596 patients filled validated Gastrointestinal Symptom Rating Scale and...

The aim of this study was to compare the efficacy of the branded and a generic extended-release ropinirole formulation in the treatment of advanced Parkinson's disease (PD). Of 22 enrolled patients 21 completed the study. A rater blinded to treatment evaluated Unified Parkinson's Disease Rating Scale, Fahn-Tolosa-Marin Tremor Rating Scale, Nonmotor Symptoms Assessment Scale, and a structured qu...

Objectives: Many aspects of pediatric colonoscopy differ from adult Responses were analyzed and re-sent to the panel for further ratings until consensus was reached. Items that 80% of experts rated as 4 out of 5 were included in the final instrument. Consensus items were compared with those expert consensus regarding items required on a checklist and global rating scale designed to assess the c...

Gut microbiome alterations observed in patients with psoriasis might contribute to the disease pathogenesis through an increased intestinal permeability and translocation of several bacterial metabolites. The aim study was assess gut barrier dysfunction, concentration microbiota-derived metabolites their possible association clinical manifestations comorbidities psoriasis. One hundred twenty mo...

how to cite this article: imanzadeh f. gastrointestinal symptoms in lysosmal disease. iran j child neurol autumn 2012; 6:4 (suppl. 1):17-18. pls see pdf.   references: 1. semenza  gl,  pyeritz  re.  respiratory complications of mucopolysaccharide storage disorders. medicine (baltimore) 1988; 67:209. 2.   wraith   je,   scarpa   m,   beck   m,   et   al. mucopolysaccharidosis type ii (hunter syn...

INTRODUCTION An increasing number of generic alendronate formulations have become available. Although expected to have the same tolerability and efficacy, head-to head comparison of generic and brand alendronate was never performed. Therefore, we compared the tolerability and efficacy of generic and brand alendronate. METHODS In a randomized double-blinded single centre cross-over study in 37...

Abstract Background Many patients with chronic insomnia disorder (CID) have gastrointestinal (GI) symptoms. First-line medications do not treat GI problems. Acupuncture has a comprehensive regulative action on both CID and is receiving increasing attention. Recent studies indicate that diseases may cause abnormal brain activity. However, the neurological mechanism underlying effect of acupunctu...

BACKGROUND Two open-label studies demonstrated that conversion from mycophenolate mofetil (MMF) to enteric-coated mycophenolate sodium (EC-MPS) significantly reduces gastrointestinal (GI) symptom burden and improves GI-specific health-related quality of life. Using a randomized design, this study evaluated changes in GI symptoms and health-related quality of life in patients converted from MMF ...