Gemfibrozil (GEM) is a clofibrate analog used to treat moderate to severe hypertriglyceridemias. In lab animals, GEM causes peroxisome proliferation, an effect that has been associated with hepatocarcinogenesis in rats. In humans, hepatobiliary disorders, but not carcinogenesis, have been associated with GEM therapy. In the present study [14C]GEM was administered orally to rats at a dose of 200...

The emerging albumin nanoparticle brings new hope for the delivery of antitumor drugs. However, a lack of robust tumor targeting greatly limits its application. In this paper, cyclic arginine-glycine-aspartic-conjugated, gemcitabine-loaded human serum albumin nanoparticles (cRGD-Gem-HSA-NPs) were successfully prepared, characterized, and tested in vitro in the BxPC-3 cell line. Initially, 4-N-m...

We report the first measurements of electron transparency, ion transparency and ion feedback of a mass produced 3M GEM. Our results indicate that a mass produced GEM and a CERN GEM have similar values of these three quantities. r 2004 Elsevier B.V. All rights reserved. PACS: 29.40. n; 29.40.Cs; 29.40.Gx; 95.55.Vj; 85.60.Ha

Gemcitabine resistance is a common problem of pancreatic cancer chemotherapy, and how to reverse it plays an important role in the treatment of pancreatic cancer. This study investigated the effect of emodin on the gemcitabine-resistant pancreatic cancer cell line SW1990/Gem, and explored the potential mechanism of its action. SW1990/Gem was obtained by culture of the pancreatic cancer cell lin...

INTRODUCTION Interprofessional patient care is a well-recognized path that health care systems are striving toward. The Veteran's Affairs (VA) system initiated interprofessional practice (IPP) models with their Geriatric Evaluation and Management (GEM) programs. GEM programs incorporate a range of specialties, including but not limited to, medicine, nursing, social work, physical therapy and ph...

Investigation of potential therapeutics for targeting breast cancer stem cells (BCSCs) is important because these cells are regarded as culprit of breast cancer relapse. Accomplishing this kind of strategy requires a specific drug-delivery system using the distinct features of liposomes. Studies on targeted liposomal delivery systems have indicated the conjugation of hyaluronan (HA), a primary ...

Biliary tract carcinoma is a relatively rare tumor with a poor prognosis. Surgical resection is the only potential cure. However, the efficacy of chemotherapeutic agents is disappointing in advanced or recurrent cases. Gemcitabine (GEM) appears to be one of the most promising chemotherapeutic agents in biliary tract carcinoma, and ribonucleotide reductase subunit M1 (RRM1) plays an important ro...

The Graphics Environment for Max, or GEM, is a real-time computer graphics language which operates under the SGI version of Max. GEM supports abstract computer graphics as well as image and pixel manipulations, enabling the user to control the graphics as objects, instead of as a sequence of vertices. Because it maintains the Max paradigm, GEM is an easy to use development environment.

In my thesis project, I provide a description of the entire process of materials preparation, assembly, testing, and characterization of several triple-GEM (Gas-Electron Multiplier) prototype detectors. GEM detectors represent one of the latest developments in a new style of gaseous particle detectors. They have become well-known and widely used. Improvements in foil production are important fo...