Melanocortin-3 receptor (MC3R) plays an important role in the central control of energy homeostasis, and several functional polymorphisms of this gene have been detected. We have studied MC3R as a candidate gene responsible for variation in economically important traits in chicken. To determine the association between MC3R polymorphism and phenotypic variation, a total of 190 individuals from b...

Single nucleotide polymorphisms (SNPs) may be used in biodiversity studies and commercial tasks like traceability, paternity testing and selection for suitable genotypes. Twenty-seven SNPs were characterized and genotyped on 250 individuals belonging to eight Italian goat breeds. Multilocus genotype data were used to infer population structure and assign individuals to populations. To estimate ...

Different methods for genomic evaluation were compared for accuracy and feasibility of evaluation using phenotypic, pedigree, and genomic information for a trait influenced by a maternal effect. A simulated population was constructed that included 15,800 animals in 5 generations. Genotypes from 45,000 SNP were available for 1,500 animals in the last 3 generations. Genotyped animals in the last ...

Genotyping for five short tandem repeat (STR) loci HUMvWA, HUMFES, HUMTPO, HUMTH01 and D3S1359 was done in 220 unrelated individuals from the population of Isfahan province of IR Iran. The loci were genotyped using the polymerase chain reaction (PCR) followed by polyacrylamide gel electrophoresis (PAGE) and silver staining. The data demonstrated that the STR markers were all found informative i...

objective: people are usually susceptible to carcinogenic aromatic amines, present in cigarrette smoke and polluted environment, which can cause dna damage. therefore, maintenance of genomic dna integrity is a direct result of proper function of dna repair enzymes. polymorphic diversity could affect the function of repair enzymes and thus augment the risk of different cancers. xeroderma pigment...

BACKGROUND Adiponectin is an adipokine with insulin-sensitising and anti-atherogenic effects. Two receptors for adiponectin, ADIPOR1 and ADIPOR2, have been characterized that mediate effects of adiponectin in various tissues. We examined whether genetic variation in ADIPOR2 predicts the development of cardiovascular disease (CVD) and/or Type 2 Diabetes (T2DM) in individuals with impaired glucos...

aim : the purpose of this study was to compare the distribution of interleukin (il)-28b genotypes between iranian healthy individuals and patients with chronic hepatitis c based on the genotype. background : polymorphisms in the region of il-28b gene have been identified as the strongest genetic pretreatment predictor of sustained virological response (svr) in hepatitis c infection. patients an...

The Genetic Analysis Workshop 15 rheumatoid arthritis data included a set of 460 cases and 460 controls genotyped at 2300 closely spaced markers on a 10 megabase region of chromosome 18q. We conducted a multilocus analysis of these data using a localized haplotype clustering method that adapts to linkage disequilibrium structure and can be applied to large, densely genotyped data sets such as t...

Landscape genetics is a new discipline that aims to provide information on how landscape and environmental features influence population genetic structure. The first key step of landscape genetics is the spatial detection and location of genetic discontinuities between populations. However, efficient methods for achieving this task are lacking. In this article, we first clarify what is conceptu...