Allogeneic hematopoietic stem cell transplant is safe and curative treatment modality for many hematologic diseases. Expanding alternative donor options such as haploidentical hematopoietic stem cell transplantation and umbilical cord blood, taken together with enhanced outcomes of matched unrelated donors, has resulted in a advisable donor for most patients with an hematopoietic stem cell tran...

BACKGROUND Hematopoietic stem and progenitor cells can interact with their microenvironment via integrins which are adhesion receptors consisting of alpha and beta subunits. Current knowledge suggests that the integrin subunits alpha4 and alpha6 expressed on hematopoietic stem and progenitor cells have distinct roles in retaining stem cells in the bone marrow. The aim of our study was to gain i...

embryonic stem cells (escs) as pluripotent stem cells have the potential to give rise to all three germ layer cells. also, these cells have the self-renewing ability. escs could differentiate into most of cell lineages. lymphocytes generated from hematopoietic stem cells. we designed a feeder free culture condition to generate lymphoid lineage cells from escs. we demonstrated that il-7 plays cr...

introduction: umbilical cord blood (cb) has been identified as a rich source for hematopoietic stem cells (hscs), and has provided an alternative to bone marrow transplantation. the use of ex vivo expanded cells has been suggested as a possible means to accelerate the speed of engraftment in cord blood (cb) transplantation. the main aim of our study is to find the best culture media and conditi...

The objective of the research was to determine effect educational intervention based on Bandura’s Social Cognitive Learning Theory care dependency and symptom management after hematopoietic stem cell transplantation.
 Methods. This randomized controlled trial conducted between January 2019 February 2020 at Hematopoietic Stem Cell Transplantation Center. All patients were randomly divided i...

Successful expansion of hematopoietic stem cells would benefit the use of hematopoietic stem cell transplants in the clinic. Several angiopoietin-like proteins, including angiopoietin-like 7, can support the activity of hematopoietic stem cells. However, effects of ANGPTL7 on human hematopoietic stem cells and the downstream signaling cascade activated by ANGPTL7 are poorly understood. Here, we...

organ transplantation is a widely undertaken procedure and has become an important alternative for the treatment of different end-stage organ diseases that previously had a poor prognosis. the field of organ transplant and hematopoietic stem cell transplant is developing rapidly. the increase in the number of transplant recipients also has an impact on oral and dental services. most of the oral...

Hematopoiesis is the process of blood cell production, which involves the maintenance and proliferation of hematopoietic progenitor cells and their differentiation into mature, functional erythrocytes, leukocytes, and platelets. Normal hematopoiesis depends on the presence of (1) normal pluripotent hematopoietic stem cells, which are capable of maintaining differentiated hematopoietic cell prod...

Eicosanoids have been implicated in the physiological regulation of hematopoiesis with pleiotropic effects on hematopoietic stem cells and various classes of lineage restricted progenitor cells. Herein we review the effects of eicosanoids on hematopoiesis, focusing on new findings implicating prostaglandin E(2) in enhancing hematopoietic stem cell engraftment by enhancing stem cell homing, surv...