In hepatitis C virus (HCV) infection, virus load and the risk for HCV-related end-stage liver disease (ESLD) are increased among persons with human immunodeficiency virus (HIV) coinfection. To clarify these relationships, 42 hemophilic patients who developed ESLD and random samples from 164 hemophilic patients with HCV infection alone and 146 with HCV-HIV coinfection were tested for HCV load an...

Therapeutic effectiveness of factor VIII inhibitor bypassing materials has been evaluated in dogs with hemophilia A. A standardized template gingival biopsy was performed using local anesthesia. Hemophilic dogs bled extensively from the biopsy site, whereas in normal dogs the wound was sealed within 5 + /- 2 min. If untreated, the hemophilic dogs frequently bled for several days. Factor VIII in...

We report a case of hemophilic pseudotumor in the ulna of a 6-year-old boy treated with radiation therapy. A total dose of 900 cGy in 6 fractions was given in 6 consecutive days. Progression of cystic changes was halted within a month. New bone formation and trabeculation were found on the 4th month. Complete healing of the lesion and bony replacement were found on the 12th month. The patient w...

To prevent hemophilic arthropathy, prophylactic treatment of children with severe hemophilia should be started before joint damage has occurred. However, treatment is expensive, and the burden of regular venipunctures in young children is high. With the aim of providing information on starting prophylaxis on the basis of individual patient characteristics, the effect of postponing prophylaxis o...

Background Hemophilia A and B are disorders resulting from a deficiency in factor VIII (FVIII), and factor IX (FIX), respectively. Tissue Factor (TF) is a key component of the extrinsic pathway and plays a role in the coagulation defect of hemophilic blood. Neutralizing the activity of TFPI represents a promising treatment concept in patients with hereditary or acquired hemophilia. ARC19499 is ...

Hemophilic pseudotumor or “blood cysts”, described by Starker1 are a rare complication of Hemophilia, observed in only 1-2% of patients with severe disease,2 consisting of extravasated clotted blood surrounded by a fibrous capsule. It affects bones, lungs, and abdomen and stomach wall. Morbidity occurs by compression on surrounding structures including bone destruction, muscle and skin necrosis...

Hemophilic pseudotumor is a term used to describe a progressive, encapsulated, slowly expanding, cystic mass occurring as a result of recurrent hemorrhage, usually in soft tissues but occasionally in bone or subperiosteal location. It is an uncommon but serious complication of bleeding diathesis occurring in only 1 2% cases and has mostly been reported in severe factor VIII and IX deficiency. W...

Factor VIII C domains contain key binding sites for von Willebrand factor (vWF) and phospholipid membranes. Hemophilic patients were screened for factor VIII C-domain mutations to provide a well-characterized series. Mutated residues were localized to the high-resolution C2 structure and to a homology model of C1. Of 30 families found with mutations in the C domains, there were 14 missense chan...

Antihemophilic factor (AHF, factor VIII) is a macromolecule that can be dissociated into two subcomponents. One, of high molecular weight (MW), forms precipitates with heterologous antiserum against AHF and supports ristocetin-induced aggregation of platelets. The other, of lower MW, has procoagulant activity. The plasma of patients with classic hemophilia contains a form of AHF with properties...