FHTG: familial hypertriglyceridemia HDL: high-density lipoprotein LCH: Langerhan’s cell histiocytosis LDL: low-density lipoprotein VLDL: very low-density lipoprotein XD: xanthoma disseminatum INTRODUCTION Xanthoma disseminatum (XD) is a rare subtype of non-Langerhan’s cell histiocytosis (non-LCH). To date, just greater than 100 cases of XD have been reported; however, association with hyperlipi...

Langerhan’s Cell Histiocytosis formerly known as histiocytosis X traditionally denotes a group of diseases that stem from proliferative reticuloendothelial disturbances. The etiology and pathogenesis of the disease remain debatable.The present paper reports a case occuring in a three and a half year old ( 31⁄2 year pediatric) child reported to the department of oral pathology with gingival enla...

langerhans cell histiocytosis is a relatively rare unique disease process characterized by an abnormal proliferation of immature dendritic cells usually affecting children and young adults. jaws are involved in less than 10% of children with the disease while mandibular involvement in young children is uncommon and bilateral affection is very rare. the purpose of this report is to describe a un...

PURPOSE To describe the involvement of the cerebellum by a gliotic and demyelinating process in Langerhans cell histiocytosis. METHODS A retrospective analysis of all (N = 30) cases of Langerhans cell histiocytosis followed at our institution since 1975 yielded four patients with CT and/or MR evidence of cerebellar abnormalities. RESULTS Four patients manifested strikingly similar findings ...

Nasal biopsy findings in malignant histiocytosis presenting clinically as lethal midline granuloma are characterised by necrosis and infiltration of atypical histiocytic cells with a diffuse positive reaction for non-specific esterase. This cellular character was common to midline malignant reticulosis, and midline malignant reticulosis and malignant histiocytosis are thought to be the same dis...

A 45-year old male presented latero-cervical lymphoadenopathy. Biopsy revealed a malignant proliferation of immature "lymphoid" cells bearing T6 antigen and HLA-DR but negative for other lymphoid markers, suggesting a phenotype similar to Langerhans cells. The patient did not receive any therapy and six months later developed a histologically typical malignant histiocytosis, involving spleen an...

Smoking-induced diffuse interstitial lung processes include respiratory bronchiolitis, respiratory bronchiolitis-associated interstitial lung disease (RBILD), desquamative interstitial pneumonia (DIP) and Langerhans' cell histiocytosis. The histological, radiological and clinical features of respiratory bronchiolitis, RBILD and DIP are reviewed, with particular reference to management issues; L...

Langerhan's cell histiocytosis (LCH) results from the proliferation of immunophenotypically and functionally immature, morphologically rounded Langerhan's cells along with eosinophils, macrophages, lymphocytes, and, commonly, multinucleated giant cells. Here we report a case in a 6-year-old boy of differential diagnoses including dermatopathic lymphadenitis (DL), parasitic infection, Kimura's d...