Objective: The present research work is focused to develop in situ raft gel of lafutidine. Sodium alginate one the critical components for development system. Methods: formulation was prepared using hydrophilic polymers such as ethyl cellulose, HPMC K4M, and chitosan. formulations were subjected evaluation characteristics pH, vitro gelling time, viscosity, density, strength, drug-polymer compat...

Tizanidine hydrochloride is an orally administered prokinetic agent that facilitates or restores motility through-out the length of the gastrointestinal tract. The objective of the present investigation was to develop effervescent floating matrix tablets of tizanidine hydrochloride for prolongation of gastric residence time in order to overcome its low bioavailability (34-40 %) and short biolog...

The aim of the present study was to prepare and evaluate an osmotically controlled mucoadhesive cup-core (OCMC) containing aceclofenac. A special technique was used while preparing an OCMC. Stability of OCMC was determined in natural human saliva, and it was found that both pH and device are stable in human saliva. OCMC was evaluated by weight uniformity, thickness, hardness, friability, swelli...

The aim of the present work was to prepare and evaluate sustained release liquisolid compact formulations of tramadol hydrochloride. The dissolution profile of the prepared compacts was also compared to that of a marketed preparation. Liquisolid sustained release formulations were prepared by using HPMC K4M as a sustained release agent. Precompression studies of characteristics such as flow pro...

The purpose of the study was to prepare and evaluate clarithromycin (CLA) floating tablets using experimental mixture design for treatment of Helicobacter pylori provided by prolonged gastric residence time and controlled plasma level. Ten different formulations were generated based on different molecular weight of hypromellose (HPMC K100, K4M, K15M) by using simplex lattice design (a sub-class...

Objective: Buccal drug delivery is the most suited route for local as well systemic of drugs. Cilnidipine an L/N type dihydropyridine 4th generation calcium channel blocker (CCB), which decreases hypertension by blocking N-type to attenuate vascular sympathetic neurotransmission. It has high first-pass metabolism leading low bioavailability. Hence present research work was undertaken formulate ...

The purpose of the study was to prolong the gastric residence time and increase the bioavailability of atenolol by designing its floating tablets and to study the influence of different polymers on its release rate. It was selected as a model drug, because it is poorly absorbed from the lower GIT. The tablets were prepared by direct compression technique, using different polymers such as hydrox...

The influence of polyvinylpyrrolidone (PVP), a commonly used binder and adhesive, on the aggregation of spheroids coated with hydroxypropylmethylcellulose (HPMC) was studied. The aggregation propensities of spheroids coated by HPMC alone and by HPMC with polyethylene glycol (PEG) were compared with those coated by HPMC with PVP and the viscosity of the coating solutions determined. The coating ...

Hydroxypropylmethylcellulose (HPMC) and methylcellulose (MC) are modified cellulose dietary fibers that generate viscous solutions in the gastrointestinal (GI) tract. This study assessed the effects of high viscosity (HV) HPMC, ultra-HV (UHV) HPMC, and medium viscosity MC on postprandial glucose and insulin responses in overweight and obese men and women (n = 50). After overnight fasts, subject...

Various methods are available to formulate water soluble drugs into sustained release dosage forms by retarding the dissolution rate. One of the methods used to control drug release and thereby prolong therapeutic activity is to use hydrophilic and lipophilic polymers. In this study, the effects of various polymers such as hydroxypropyl methylcellulose (HPMC), ethylcellulose (EC) and sodium car...