نتایج جستجو برای: hpmc k4m
تعداد نتایج: 1352 فیلتر نتایج به سال:
Ketoprofen is a potent non-steroidal anti-inflammatory drug which is used for the treatment of rheumatoid arthritis. The oral administration of ketoprofen can cause gastric irritation and renal adverse effects. Topical application of the drug can bypass gastrointestinal disturbances and provide relatively consistent drug levels at the site of action. Since the efficacy of gels depends on the ty...
Objective: The objective of the present study was to formulate a controlled release floating tablet of Olmesartan Medoxomil. Methods: Floating tablets of Olmesartan Medoxomil were prepared by direct compression method using both natural (sodium alginate and carrageenan) and semi synthetic polymers (HPMC K4M, HPMC K100LV and HPMC E50LV).Sodium bicarbonate and calcium carbonate were used as gas g...
Purpose: To comparatively evaluate the effect of two hydroxylpropyl methylcellulose (HPMC) molecular weight grades (K4M and K15M) on drug release from diclofenac sodium matrix tablets. Methods: Tablets containing diclofenac sodium were prepared by direct compression method at various drug/HPMC ratios and evaluated in vitro for their water uptake, erosion and dissolution characteristics over a p...
Lamivudine, a BCS Class I synthetic nucleoside analogue, has a a short biological half-life of 5–7 and is mainly absorbed in the upper gastrointestinal tract. The purpose of the study is to develop a controlled release floating tablets of lamivudine employing HPMC K4M and sodium alginate. The floating tablets of lamivudine were prepared employing HPMC K4M and sodium alginate as matrix formers a...
Background and purpose: Buccal delivery of drug provides an attractive alternative to the oral route of drug administration and a convenient route of administration for both systemic and local drug delivery. Absorption of therapeutic agents from the oral cavity provides a direct entry for such agents into the systemic circulation, thereby avoiding first-pass metabolism and gastrointestinal d...
Study aims to design a Gastro retentive Drug Delivery System of Cefuroxime axetil (CA). CA is a broad spectrum beta lactam type of antibiotic. More specifically, it is a second-generation cephalosporin. CA has site specific absorption from upper gastro intestinal tract and in intestine it undergoes hydrolysis to cefuroxime having poor absorption. Unabsorbed drug causes high concentration of ant...
The present study deals with the formulation and of oromucosal tablets Rizatriptan Benzoate (RB) using different bioahdesive polymer. Nine formulations were prepared by direct compression method. Hydroxypropyl methyl cellulose (HPMC K4M), Gum acacia Sodium Alginate used as buccal mucoadhesive Ethyl (EC) an impermeable backing layer. FTIR Studies showed no interaction drug, polymer excipients. 3...
The aim of the present study was to formulate and evaluate nystatin containing thermosensitive mucoadhesive gel for vaginal drug delivery to achieve prolonging the residence time, sustained drug release, enhancing efficacy, decreasing recurrence, and increasing patient compliance in the treatment for vaginal candidiasis. Here nystatin (1%) as a model drug. A 3 full factorial design was employed...
Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor, primarily used for the treatment of hypertension, congestive heart failure, and heart attack. It belongs to BCS class III having a half-life of 12 hrs and 25% bioavailability. The purpose of the present work was to develop a press-coated, floating-pulsatile drug delivery system. The core tablet was formulated using the super-disint...
The floating microballoons have been utilized to obtain prolonged and uniform release in the stomach. The objective of the present study involves design, development, and characterization of pentoxifylline loaded floating microballoons to prolong their gastric residence time. Pentoxifylline (trisubstituted xanthine derivative) loaded microballoons were prepared by the solvent evaporation techni...
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