Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by motor and non-motor symptoms. It is expected to impose an increasing economic and social burden on human populations. The motor symptoms of PD are well known, including age-dependent uncontrollable resting tremor, bradykinesia, rigidity, posture instability. In the non-motor symptoms, cognitive changes, d...

dental tissues provide an alternate source of stem cells compared with bone marrow and have a similar potency as that of bone marrow derived mesenchymal stem cells. it has been established there are six types of dental stem cells: dental pulp stem cells, stem cells from human exfoliated deciduous teeth, stem cells from apical papilla, periodontal ligament stem cells, dental follicle progenitor ...

New blood forming vessels are produced by differentiation of mesodermal precursor cells to angioblasts that become endothelial cells (ECs) which in turn give rise to primitive capillary network. Human cord blood (HCB) contains large subsets of mononuclear cells (MNCs) that can be differentiated into endothelial-like cells in vitro. Human mononuclear progenitor cells were purified from fresh umb...

The major goal of the Chromosome-Centric Human Proteome Project (C-HPP) is to systematically map the entire human proteome with the intent to enhance our understanding of human biology at the cellular level. However, this goal may be hindered by the lack of quality observations of given proteins due to absence of expression in a given tissue, very low abundance, and expression only in rare samp...

The extract of pluripotent stem cells induces dedifferentiation of somatic cells with restricted plasticity. In this study, we used the extract of human embryonic stem cells (hESC) to dedifferentiate adipose tissue-derived stem cells (ADSCs) and examined the impact of this reprogramming event on dopaminergic differentiation of the cells. For this purpose, cytoplasmic extract of ESCs was prepare...

background: limited resources for adult stem cells necessitate their in vitro culture prior to clinical use. investigating mitochondrial dna (mtdna) and telomere shortening has proved to be important indications of stem cell validity. this study was designed to investigate these indicators in multiple passages of three adult stem cell lines which were produced in our stem cell laboratory. metho...

Regenerative capacity of mammals is limited and can rarely regenerate a specific organ or tissue fully. Due to these limitations, regenerative medicine seeks efficient and safe cell sources for regeneration of damaged tissues and organs or treatment for incurable diseases. Human embryonic stem cells (HESCs) hold two important properties called self renewal and pluripotency. However, the use of ...