HUMAN beings with hyperadrenocorticism (e.g. Cushing's syndrome) frequently develop premature, severe atherosclerosis.7' 8 This fact assumes new importance at the present time, when chronic hyperadrenocortical states are being artificially induced on a large scale for therapeutic purposes. The widespread utilization of corticotropin (ACTH) and adrenal steroids in clinical medicine compels a tho...

HUMAN beings with hyperadrenocorticism (e.g. Cushing's syndrome) frequently develop premature, severe atherosclerosis.7' 8 This fact assumes new importance at the present time, when chronic hyperadrenocortical states are being artificially induced on a large scale for therapeutic purposes. The widespread utilization of corticotropin (ACTH) and adrenal steroids in clinical medicine compels a tho...

We have demonstrated previously that many human cancer cell lines maintained in tissue culture possess specific cell surface receptors for human prolactin (HPRL) and human growth hor mone (HGH). In the present studies, the biological response in vitro of one human breast cancer cell line, T-47D, to the two pituitary hormones was examined. T-47D cells, when grown on tissue culture dishes, displa...

Abstract Corticosteroids are anti-inflammatory and immunosuppressant drugs. Topical corticosteroids formulations (ointments, creams, gels) used in the treatment of different types dermatitis urticaria. Considering their therapeutic whitening effects, they frequently for counterfeiting cosmetic products. can cause local systemic side effects. HPLC method is often chosen analysis, because it sele...

The goal of hormone replacement is to mirror physiology. Hydrocortisone granules and modified release formulations are being developed optimise cortisol in the rare disease adrenal insufficiency. To facilitate clinical development, we built verified a physiologically based pharmacokinetic (PBPK) model for endogenous (hydrocortisone) healthy adults, children adults with predicted immediate-relea...

Introduction: Cardiac preconditioning is an important method to reduce the damage caused by prolonged ischemia. Previous studies have shown that corticosteroids have protective effects on the heart, however at high concentrations this effect may be reduced with unknown mechanisms. We hypothesize that the contradictory effects of hydrocortisone at high concentration may be mediated via minera...