Vahid Khori
Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
[ 1 ] - Hydro-alcoholic extract of Matricaria recutita exhibited dual anti-spasmodic effect via modulation of Ca2+ channels, NO and PKA2-kinase pathway in rabbit jejunum
Objective: Several studies have shown the antispasmodic activity of Matricariarecutita without detailing the underlying mechanism(s). The present study was designed to determine whether the antispasmodic mechanisms of M. recutita extract mediated via histaminergic/cholinergic receptors, Ca2+channels, activation of PKA2 and NO release in isolated rabbit jejunum. Methods and Materials: The concen...
[ 2 ] - اثرات الکتروفیزیولوژیک وابسته به سرعت زعفران ((Crocus sativus L. بر روی پتانسیل عمل میدانی خارج سلولی قلب جدا شده خرگوش در شرایط برون‌تنی
مقدمه: گیاهان دارویی به علت سهولت دسترسی، کاهش عوارض جانبی و قیمت مناسب به عنوان جاگزین‌های شایسته داروهای سنتتیک همواره مورد توجه بوده‌اند. مواد بیولوژیک با منشاء گیاهی یک شاخه اصلی از فارماکوتراپی مدرن بیماری‌های قلبی و عروقی را شامل می‌شود. هدف: هدف از تحقیق حاضر تعیین نقش ضدآریتمی عصاره هیدرو الکلی زعفران در مدل گره دهلیزی - بطنی ایزوله خرگوش نر می‌باشد. روش بررسی: در این مطالعه از خرگوش...
[ 3 ] - نقش آنزیم سازنده نیتریک اکسید در خواص ضدآریتمی زعفران (Crocus Sativus) بر گره دهلیزی- بطنی قلب جدا شده خرگوش
چکیده مقدمه: اکسید نیتریک به‌صورت مستقیم و غیرمستقیم قادر است خواص الکتروفیزیولوژی قلب را متاًثر کند. از طرف دیگر آنزیم‌های سازنده اکسید نیتریک در گره دهلیزی- بطنی نشان داده شدند. بررسی‌های مختلف نشانگر اثر کاهنده فشار خون و ضد ایسکمی زعفران است. هدف: تعیین اثرات عصاره هیدرو الکلی زعفران بر خواص پایه و کارکردی گره دهلیزی- بطنی و نقش نیتریک اکسید در مکانیسم اثرات زعفران مواد و روش‌ها: در این م...
[ 4 ] - اثرات وابسته به سرعت آنتی آریتمی چرخشی گره دهلیزی بطنی سیمواستاتین در مدل گره دهلیزی بطنی ایزوله خرگوش
Background and purpose: Several previous studies have shown the direct and indirect effects of statins on supraventricular and ventricular arrhythmia. The purpose of the present study is to determine (1) whether Simvastatin modifies the rate-dependent properties of the ÂV node, (2) to what extent such changes are related to effect of Simvastatin on the basic properties of ÂV nodal conduction ...
[ 5 ] - نقش رسپتورهای آدرنرژیک در اثرات الکتروفیزیولوژیک عصاره در مدل آزمایشگاهی (Citrus bigaradia) هیدروالکلی بهارنارنج فیبریلاسیون دهلیزی گره دهلیزی بطنی جدا شده خرگوش
Background and purpose: Preliminary studies have been established to examine the cardiotonic effect of Citrus bigaradia extract, by implenenting various mechanisms. The functional protective role of this plant against supraventricular tachyarrhythmia remains to be determined.The present study is designed to assess the role of hydroalcoholic extract of Citrus bigaradia by modifing the electrop...
[ 6 ] - نقش پمپ سدیم - پتاسیم وابسته به انرژی در اثرات عصاره هیدروالکلی ریشه گزنه بر روی گره دهلیزی بطنی جدا شده خرگوش نر
Background and Purpose: Previous studies have demonstrated the cardiovascular effects of Urtica dioica (Nettle) such as anti-hypertensive, and negative inotropic effects on heart . The effects of plant on atrioventricular node has not been explored yet.Inhibitory Na+-K+-ATPas pump has been shown ny U. dioica . The aims of the present study were: 1) to determine concentration-dependent e...
[ 7 ] - تاثیر عصاره آبی زعفران (Croueus sativus) روی خواص الکتروفیزیولوژیک پایه و کارکردی گسترده جداشده گره دهلیزی– بطنی خرگوش
زمینه و هدف: گیاهان دارویی، به علت سهولت دسترسی، کاهش عوارض جانبی و قیمت مناسب، به عنوان جایگزین شایسته داروهای سنتتیک، همواره مورد توجه بوده اند. مواد بیولوژیک گیاهی با منشا گیاهی یک شاخه اصلی از فارماکوتراپی مدرن بیماری های قلبی عروقی را شامل می شوند. هدف از این مطالعه تعیین اثرات عصاره آبی زعفران روی خواص پایه و کارکردی گروه دهلیزی بطنی بود.روش بررسی: در این مطالعه تجربی از 17 سر خرگوش نر نی...
[ 8 ] - اثرات اسانس گل بهار نارنج (Citrus aurantium) روی خواص الکتروفیزیولوژیک کره دهلیزی – بطنی خرگوش
زمینه و هدف: گزارش های متعدد در منابع مختلف در مورد اثرات قلبی و عروقی گیاه بهار نارنج (Citrus aurantium) اشاره شده است. در مطالعه حاضر اثرات غلظت های مختلف (0.3، 0.2 و 0.1) اسانس این گیاه روی خواص الکتروفیزولوژیک گره دهلیزی بطنی با کمک مدل گره دهلیزی- بطنی ایزوله خرگوش مورد مطالعه قرار گرفت. هدف دوم مطالعه حاضر بررسی نقش حفاظتی اسانس بهار نارنج در اثرات آریتموژن اوبایین بود.روش بررسی: این مطال...
[ 9 ] - Role of mineralocorticoid receptors in the mediation of acute effects of hydrocortisone in isolated ischemic rat heart
Introduction: Cardiac preconditioning is an important method to reduce the damage caused by prolonged ischemia. Previous studies have shown that corticosteroids have protective effects on the heart, however at high concentrations this effect may be reduced with unknown mechanisms. We hypothesize that the contradictory effects of hydrocortisone at high concentration may be mediated via minera...
[ 10 ] - Modulation of extracellular atrioventricular node field potential pattern and ventricular rhythm by morphine in experimental atrial fibrillation in isolated rabbit heart
Introduction: Endorphins are produced by cardiomyocytes, and exert different effects on the heart. The aim of the present study is to assess morphine effects on extracellular atrioventricular (AV) node field potential pattern and ventricular rhythm of isolated rabbit heart during experimental atrial fibrillation (AF). Methods: Effects of different concentrations of morphine (10, 20, 50 and 1...
[ 11 ] - New manifestations of electrophysiological remodeling of heart during experimental model of atrial fibrillation in cirrhotic rat isolated heart
Introduction: The present study is aimed to evaluate electrophysiological remodeling of atrioventricular (AV) node and ventricular conduction during experimental atrial fibrillation (AF) model in isolated heart of cirrhotic rats. Methods: Cirrhosis-induced electrophysiological remodeling was evaluated in 24 isolated retrogradely perfused rat hearts in 2 groups (control and cirrhotic). Cirrho...
[ 12 ] - A novel isolated dual perfusion/superfusion heart model for physiological and pharmacological evaluation of mammalian heart preparations
Abstract Introduction: Isolated perfused heart models such as perfusion and superfusion are commonly used for mammalian heart research. However, there are several fundamental limitations in the current techniques. In perfusion model, a suitable cannula is connected to the aorta and the perfusion is retrogradely performed. But, electrode displacement is a potential unwanted event resulted fr...
[ 13 ] - Preconditioning effects of oxytocin in reducing cardiac arrhythmias in a rat heart regional ischemia-reperfusion model
Abstract Introduction: Occurrence of cardiac arrhythmias and myocardial infarction are two main deleterious events that are caused by ischemia-reperfusion (IR) injury in the heart. Cardiac preconditioning represents the most potent method of rescuing heart tissue from undergoing irreversible ischemic damage. The aim of the present study was to evaluate oxytocin (OT) cardioprotective effect...
[ 14 ] - Frequency-dependent electrophysiological properties of concealed slow pathway of isolated rabbit atrioventricular node preparation after fast pathway ablation in a functional model
Introduction: Intranodal pathways of atrioventricular (AV) node play a vital role in the delay of conduction time in response to various atrial inputs. The present study was aimed to determine the frequency-dependent electrophysiological properties of concealed slow pathway according to a functional model of isolated rabbit atrioventricular node preparation after fast pathway ablation. Meth...
[ 15 ] - Acute direct effects of cyclosporine on extracellular field potential of isolated rabbit AV node during experimental atrial fibrillation
Introduction: Previous studies have indicated a relationship between MPTP pore and AV nodal rate-dependent properties. The aim of present study was to determine acute direct effects of cyclosporine on extracellular field potential of isolated rabbit AV node during experimental atrial fibrillation. Methods: In one group of male New Zealand rabbits (1.5-2.5 kg) cumulative concentrations of cyc...
[ 16 ] - Effect of pre-treatment with oxytocin on cardiac enzymes in regional ischemiareperfusion injury induced in the rat heart
Introduction: Cardiac preconditioning represents the most potent and consistently reproducible method of rescuing heart tissue from undergoing irreversible ischemic damage. The aim of the present study was to evaluate oxytocin (OT) induced cardioprotection and its signaling pathways on lactate dehydrogenase (LDH) and creatine kinase-MB isoenzyme (CK-MB) in the anesthetized rats. Methods: Ei...
[ 17 ] - Role of nitric oxide on the electrophysiological properties of isolated rabbit atrioventricular node by extracellular field potential during atrial fibrillation
Introduction: The aim of the present study was to determine direct effects of NO modulation on protective electrophysiological properties of atrioventricular node (AV node) in the experimental model of AF in rabbit. Methods: Isolated perfused rabbit AV nodal preparations were used in two groups. In the first group (N=7), LNAME (50μM) was applied. In the second group (N=12), different concent...
[ 18 ] - Role of Histaminegic and calcium channels in the inhibitory effects of hydroalcoholic extract of Matricaria recutita L. on isolated rabbit jejunum
Introduction: Considering the long traditional history of anti-inflammatory and anti-spasmodic effects of Matricria spices on the gastrointestinal system, the present study aimed to investigate the role of calcium channels and Histamine receptors in the inhibitory effects of hydroalcoholic dry extract of German chamomile (Matricaria recutita L.) on the isolated rabbit jejunum. Methods: All ...
[ 19 ] - Dynamic age-related changes of extracellular field potential of isolated AV-node of rabbit
Introduction: Developmental changes in atrioventricular nodal conduction time and refractoriness have been shown in several studies. Prevalence of atrioventricular nodal reentrant tachycardia (AVNRT) is clearly age-dependent. The purpose of this study was to determine developmental changes of basic and frequency-dependent electrophysiological properties of the atrioventricular node (AV-node)...
[ 20 ] - Protective role of cyclosporine on the model simulated the rotational nodal arrhythmia (AVNRT) by using extracellular field potential recordings of isolated atrioventricular-node of rabbit
Introduction: Recent studies have shown acute cardioprotective effects of cyclosporine. The aim of the present study was to determine the protective role of cyclosporine on the model simulated the rotational nodal arrhythmia (AVNRT) by using extracellular field potential recordings of isolated atrioventricular-node (AV-node) of rabbit. Methods: This study was performed on isolated double-per...
[ 21 ] - Frequency-dependent anti arrhythmic effects if Crataegus monogyna on extracellular field potential recording in experimental model of AF atrioventricular Node of rabbit.
Introduction: Despite extensive studies about effects of Crataegus monogyna on cardiovascular diseases yet, a few study has been undertaken antiarrhythmic property of this plant. Aims of the present study were: 1) To determine the protective role of methanolic extract of C.monogyna on the rate-dependent model and the concealed conduction . 2) To explore the role of Na+-K+ A TPase in the protect...
[ 22 ] - Age-dependent dynamic electrophysiological field potential behavior of atrioventricular node during experimental AF in rabbit
Introduction: Electrophysiological studies have demonstrated a relationship between aging and atrioventricular (AV) nodal conduction and refractoriness. The aim of the present study was to determine the effects of nodal aging on dynamic AV nodal field potential recording during atrial fibrillation (AF) in rabbit. Methods: Two groups of male New Zealand rabbits (neonatal 2-week-olds and adult...
[ 23 ] - Effects Of Fast Pathway Ablation On The Concealment Zone And Electrophysiological Behavior Of AV-Node During Atrial Fibrillation.
Objectives: Dual pathways have a determinant role in the occurrence of atrio nodal tachyarrhythmia (AVNRT). The aim of present study is to determine the role of slow pathway (SP) in the concealment zone and protective role of AV node during atrial fibrillation (AF). Material &Methods: In 7 isolated nodal rabbit preparation zone of concealment and concealed conduction is quantified by Specif...
[ 24 ] - Role of slow pathway after nodal fast pathway ablation on the basic and rate- dependent properties of the isolated rabbit atrioventricularNode
Introduction : The aim of this study is to obtain new insight into possible relation between functional properties of slow concealed pathway and rate-dependent properties of AV-node. Methods : Rate-dependent nodal properties of recovery, facilitation, and fatigue were characterized by stimulation protocols in one groups of (N=7) isolated superfused AV-Nodal rabbits. Small miniature lesions ...
[ 25 ] - New model of computer analysis for assessment of the effects of lesions induced by direct voltage current in isolated AV-node of rabbit
Introduction: The ablation technique is one of the important therapeutic interventions for treatment of AV Nodal tachyarrhythmia. Different animal models have been developed to study the effects of ablation on the functional interanodal structure. The aim of the present study was to develop a new model of computer analysis to produce lesions by using direct voltage in isolated perfused rabbi...
[ 26 ] - Effect of Artemisia absinthium on electrophysiological properties of isolated heart of rats
Introduction: Treatment of supraventricular arrhythmia includes wide range of medical interventions. Herbal remedies are suitable alternatives for synthetic drugs due to their availability, minimal side effects and lower price. Pharmacological studies and traditional medical literature point to the cardiovascular effects of the Artemisia absinthium L. from Compositae family of plants. Meth...
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